Latrunculin alters the actin-monomer subunit interface to prevent polymerization
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Latrunculin A treatment completely blocks ultrafast endocytosis, with no induction of membrane pit formation.
“When neurons are treated with Latrunculin A, which sequesters monomeric actin (G-actin) and perturbs F-actin formation12,13, ultrafast endocytosis fails completely, with no induction of membrane pit formation5.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [12]
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Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells
Spector, I., Shochet, N. R., Kashman, Y., & Groweiss, A. (1983) · Science · doi:10.1126/science.6681676 · Cited by 750 · see citing works
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Cassidy-Stone, A., Chipuk, J. E., Ingerman, E., Song, C., Yoo, C., Kuwana, T., Kurth, M. J., Shaw, J. T., Hinshaw, J. E., Green, D. R., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.019 · Cited by 1,200 · see citing works
Cell Wall Integrity Signaling in <i>Saccharomyces cerevisiae</i>
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136 · see citing works
Flexible nets: The roles of intrinsic disorder in protein interaction networks
Dunker, A. K., Cortese, M. S., Romero, P., Iakoucheva, L. M., & Uversky, V. N. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04948.x · Cited by 1,122 · see citing works
Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works
Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
Marchand, J.-B., Kaiser, D. A., Pollard, T. D., & Higgs, H. N. (2001) · Nature Cell Biology · doi:10.1038/35050590 · Cited by 331 · see citing works
Datta, A., Deng, S., Gopal, V., Yap, K. C.-H., Halim, C. E., Lye, M. L., Ong, M. S., Tan, T. Z., Sethi, G., Hooi, S. C., et al. (2021) · Cancers · doi:10.3390/cancers13081882 · Cited by 184 · see citing works
Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells
Silva, G., Jeney, V., Chora, Â., Larsen, R., Balla, J., & Soares, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.045344 · Cited by 137 · see citing works
Rapid macropinocytic transfer of α-synuclein to lysosomes
Bayati, A., Banks, E., Han, C., Luo, W., Reintsch, W. E., Zorca, C. E., Shlaifer, I., Del Cid Pellitero, E., Vanderperre, B., McBride, H. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111102 · Cited by 57 · see citing works
Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis
Ogunmowo, T. H., Jing, H., Raychaudhuri, S., Kusick, G. F., Imoto, Y., Li, S., Itoh, K., Ma, Y., Jafri, H., Dalva, M. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38595-2 · Cited by 51 · see citing works
Kolonko, M., Geffken, A. C., Blumer, T., Hagens, K., Schaible, U. E., & Hagedorn, M. (2014) · Cellular Microbiology · doi:10.1111/cmi.12217 · Cited by 40 · see citing works
- Authors
- Morton, W. M., Ayscough, K. R., & McLaughlin, P. J.
- Affiliations
- Wellcome Centre for Cell Biology (GB)
- University of Glasgow (GB)
- Corresponding author
- McLaughlin, Paul J.
- ORCID
- Ayscough, Kathryn R.
- Venue
- Nature Cell Biology
- Published
- 2000-05-12
- Volume
- 2
- Issue
- 6
- Pages
- 376-378
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1545247886
- Cited by
- 523
- References
- 1
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 20 · 2023: 18 · 2022: 25 · 2021: 22 · 2020: 24 · 2019: 21 · 2018: 23 · 2017: 11 · 2016: 21 · 2015: 25 · 2014: 20 · 2013: 26 · 2012: 16
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- ERA (submittedVersion)
- Science and Technology Facilities Council (submittedVersion)
- Funders
- Wellcome Trust (050934)
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- latrunculin, actin, actin polymerization, actin filament structure, actin-binding proteins, actin cytoskeleton
- MeSH terms
- Actins, Animals, Binding Sites, Biopolymers, Humans, Models, Molecular, Molecular Sequence Data, Mutation, Porifera, Protein Binding, Protein Conformation, Thiazoles, Yeasts, Gelsolin, Crystallography, X-Ray, Bridged Bicyclo Compounds, Heterocyclic, Thiazolidines
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