The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inheritance of gene density–related higher order chromatin arrangements in normal and tumor cell nuclei
Open accessAbstract
A gene density–related difference in the radial arrangement of chromosome territories (CTs) was previously described for human lymphocyte nuclei with gene-poor CT #18 located toward the nuclear periphery and gene-dense CT #19 in the nuclear interior (Croft, J.A., J.M. Bridger, S. Boyle, P. Perry, P. Teague, and W.A. Bickmore. 1999. J. Cell Biol. 145:1119–1131). Here, we analyzed the radial distribution of chromosome 18 and 19 chromatin in six normal cell types and in eight tumor cell lines, some of them with imbalances and rearrangements of the two chromosomes. Our findings demonstrate that a significant difference in the radial distribution of #18 and #19 chromatin is a common feature of higher order chromatin architecture in both normal and malignant cell types. However, in seven of eight tumor cell lines, the difference was less pronounced compared with normal cell nuclei due to a higher fraction of nuclei showing an inverted CT position, i.e., a CT #18 located more internally than a CT #19. This observation emphasizes a partial loss of radial chromatin order in tumor cell nuclei.
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Citations
Cites
Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
Jauch, A., Wienberg, J., Stanyon, R., Arnold, N., Tofanelli, S., Ishida, T., & Cremer, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8611 · Cited by 310
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Cited by
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Bolzer, A., Kreth, G., Solovei, I., Koehler, D., Saracoglu, K., Fauth, C., Müller, S., Eils, R., Cremer, C., Speicher, M. R., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030157 · Cited by 837
Self-citationDynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
Lanctôt, C., Cheutin, T., Cremer, M., Cavalli, G., & Cremer, T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2041 · Cited by 781
Self-citationCharacterization of the Drosophila melanogaster genome at the nuclear lamina
Pickersgill, H., Kalverda, B., de Wit, E., Talhout, W., Fornerod, M., & van Steensel, B. (2006) · Nature Genetics · doi:10.1038/ng1852 · Cited by 631
Long-Range Chromatin Interactions
Dekker, J., & Misteli, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019356 · Cited by 255
Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration
Achuthan, V., Perreira, J. M., Sowd, G. A., Puray-Chavez, M., McDougall, W. M., Paulucci-Holthauzen, A., Wu, X., Fadel, H. J., Poeschla, E. M., Multani, A. S., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.08.002 · Cited by 205
Metadata
- Authors
- Cremer, M., Küpper, K., Wagler, B., Wizelman, L., Hase, J. V., Weiland, Y., Kreja, L., Diebold, J., Speicher, M. R., & Cremer, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-09-01
- Volume
- 162
- Issue
- 5
- Pages
- 809-820
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2107065535
- Cited by
- 261
- References
- 1
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Cremer, M., Küpper, K., Wagler, B., Wizelman, L., Hase, J. V., Weiland, Y., Kreja, L., Diebold, J., Speicher, M. R., & Cremer, T. (2003). Inheritance of gene density–related higher order chromatin arrangements in normal and tumor cell nuclei. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200304096
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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