Long-Range Chromatin Interactions
Open accessAbstract
To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.
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Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability
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- Authors
- Dekker, J., & Misteli, T.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- National Institutes of Health (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-10
- Volume
- 7
- Issue
- 10
- Pages
- a019356
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4588061
- OpenAlex
- W2185236314
- Cited by
- 255
- References
- 150
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 31 · 2021: 24 · 2020: 24 · 2019: 28 · 2018: 20 · 2017: 20 · 2016: 30 · 2015: 8 · 2014: 1 · 2013: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Human Genome Research Institute (R01HG003143)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- long-range chromatin interactions, 3D genome organization, chromosome conformation, gene expression regulation, genome maintenance, nuclear organization, chromatin looping
- MeSH terms
- Animals, Cell Nucleolus, Cell Nucleus, Chromatin, Chromosome Mapping, Chromosomes, Gene Expression Regulation, Multigene Family, Humans, RNA, Transfer, Transcription Factors, Translocation, Genetic, Gene Library, Genomics, Mice
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