PreprintCited by 255Genomics and Chromatin DynamicsNuclear Structure and FunctionChromatin Remodeling and Cancer

Long-Range Chromatin Interactions

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Dekker, Job, Misteli, Tom·2015·Cold Spring Harbor Perspectives in Biology

Abstract

To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.

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  • Attention mechanisms may be applied on EHR data and medical ontologies to capture parent-child relationships.

    “Alternatively, attention mechanisms may be applied on EHR data and medical ontologies to capture the parent-child relationships [186, 204, 205].”

    From Graph representation learning in biomedicine and healthcare (2022) · cites this paper as [205]

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  1. Lomvardas S, Maniatis T. 2014. Epigenetics regulation in neuronal development. Cold Spring Harb Perspect Biol doi: 10.1101/cshper spect.a019489. · DOI

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Authors
Dekker, J., & Misteli, T.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • National Institutes of Health (US)
Venue
Cold Spring Harbor Perspectives in Biology
Published
2015-10
Volume
7
Issue
10
Pages
a019356
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2185236314
Cited by
255
References
150
Citations by year
2026: 11 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 31 · 2021: 24 · 2020: 24 · 2019: 28 · 2018: 20 · 2017: 20 · 2016: 30 · 2015: 8 · 2014: 1 · 2013: 1
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders
National Human Genome Research Institute (R01HG003143)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
long-range chromatin interactions, 3D genome organization, chromosome conformation, gene expression regulation, genome maintenance, nuclear organization, chromatin looping
MeSH terms
Animals, Cell Nucleolus, Cell Nucleus, Chromatin, Chromosome Mapping, Chromosomes, Gene Expression Regulation, Multigene Family, Humans, RNA, Transfer, Transcription Factors, Translocation, Genetic, Gene Library, Genomics, Mice

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