The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia
Open accessAbstract
Cell polarity is essential for generating cell diversity and for the proper function of most differentiated cell types. In many organisms, cell polarity is regulated by the atypical protein kinase C (aPKC), Bazooka (Baz/Par3), and Par6 proteins. Here, we show that Drosophila aPKC zygotic null mutants survive to mid-larval stages, where they exhibit defects in neuroblast and epithelial cell polarity. Mutant neuroblasts lack apical localization of Par6 and Lgl, and fail to exclude Miranda from the apical cortex; yet, they show normal apical crescents of Baz/Par3, Pins, Inscuteable, and Discs large and normal spindle orientation. Mutant imaginal disc epithelia have defects in apical/basal cell polarity and tissue morphology. In addition, we show that aPKC mutants show reduced cell proliferation in both neuroblasts and epithelia, the opposite of the lethal giant larvae (lgl) tumor suppressor phenotype, and that reduced aPKC levels strongly suppress most lgl cell polarity and overproliferation phenotypes.
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Citations
Cites
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · cited 4×
“Each of the Baz/Par3, Par6, and aPKC proteins is reported to bind the others in vitro (Tabuse et al., 1998; Joberty et al., 2000; Lin et al., 2000; Wodarz et al., 2000; Suzuki et al., 2001; Betschinger et al., 2003), and the three proteins are reported to be interdependent for their normal localization in C.”
BackgroundInfluentialA mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
Bilder, D., & Perrimon, N. (2000) · Nature · doi:10.1038/35001108 · Cited by 716
Integrated activity of PDZ protein complexes regulates epithelial polarity
Bilder, D., Schober, M., & Perrimon, N. (2003) · Nature Cell Biology · doi:10.1038/ncb897 · Cited by 435
Müller, H. A., & Wieschaus, E. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.1.149 · Cited by 384
Cox, R. T., Kirkpatrick, C., & Peifer, M. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.1.133 · Cited by 300 · cited 1×
“Brains and imaginal discs were dissected in Schneider’s Medium (Sigma-Aldrich), fixed for 20 min in 4% formaldehyde, and stained as described previously (Cox et al., 1996).”
MethodDlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
Albertson, R., & Doe, C. Q. (2003) · Nature Cell Biology · doi:10.1038/ncb922 · Cited by 269
Self-citation
Cited by
The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila
Bowman, S. K., Rolland, V., Betschinger, J., Kinsey, K. A., Emery, G., & Knoblich, J. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.004 · Cited by 444
Neural stem cells: balancing self-renewal with differentiation
Doe, C. Q. (2008) · Development · doi:10.1242/dev.014977 · Cited by 420
Self-citationThe Drosophila NuMA Homolog Mud Regulates Spindle Orientation in Asymmetric Cell Division
Bowman, S. K., Neumüller, R. A., Novatchkova, M., Du, Q., & Knoblich, J. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.05.005 · Cited by 305
Harris, T. J. C., & Peifer, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505127 · Cited by 295
Homem, C. C. F., Steinmann, V., Burkard, T. R., Jais, A., Esterbauer, H., & Knoblich, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.06.024 · Cited by 243
Metadata
- Authors
- Rolls, M. M., Albertson, R., Shih, H.-P., Lee, C.-Y., & Doe, C. Q.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-12-01
- Volume
- 163
- Issue
- 5
- Pages
- 1089-1098
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2063197874
- Cited by
- 283
- References
- 7
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Rolls, M. M., Albertson, R., Shih, H.-P., Lee, C.-Y., & Doe, C. Q. (2003). Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200306079
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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