The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
Open accessAbstract
Sox5 and Sox6 encode Sry-related transcription factors that redundantly promote early chondroblast differentiation. Using mouse embryos with three or four null alleles of Sox5 and Sox6, we show that they are also essential and redundant in major steps of growth plate chondrocyte differentiation. Sox5 and Sox6 promote the development of a highly proliferating pool of chondroblasts between the epiphyses and metaphyses of future long bones. This pool is the likely cellular source of growth plates. Sox5 and Sox6 permit formation of growth plate columnar zones by keeping chondroblasts proliferating and by delaying chondrocyte prehypertrophy. They allow induction of chondrocyte hypertrophy and permit formation of prehypertrophic and hypertrophic zones by delaying chondrocyte terminal differentiation induced by ossification fronts. They act, at least in part, by down-regulating Ihh signaling, Fgfr3, and Runx2 and by up-regulating Bmp6. In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones.
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Cites
Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Cited by
535 East 70th Street, C. R. B., Goldring, M., Otero, M., Plumb, D., Dragomir, C., Favero, M., EI Hachem, K., Hashimoto, K., Roach, H., Olivotto, E., et al. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a16 · Cited by 489
Transcriptional control of chondrocyte fate and differentiation
Lefebvre, V., & Smits, P. (2005) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.20048 · Cited by 476
Self-citationDy, P., Wang, W., Bhattaram, P., Wang, Q., Wang, L., Ballock, R. T., & Lefebvre, V. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.024 · Cited by 400
Self-citationSOX5 Controls the Sequential Generation of Distinct Corticofugal Neuron Subtypes
Lai, T., Jabaudon, D., Molyneaux, B. J., Azim, E., Arlotta, P., Menezes, J. R. L., & Macklis, J. D. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.023 · Cited by 300
Liu, C.-F., & Lefebvre, V. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv688 · Cited by 287
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Metadata
- Authors
- Smits, P., Dy, P., Mitra, S., & Lefebvre, V.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-03-01
- Volume
- 164
- Issue
- 5
- Pages
- 747-758
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2078331675
- Cited by
- 172
- References
- 1
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Smits, P., Dy, P., Mitra, S., & Lefebvre, V. (2004). Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200312045
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