The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Transcriptional control of chondrocyte fate and differentiation
Open accessAbstract
Chondrogenesis is an essential process in vertebrates. It leads to the formation of cartilage growth plates, which drive body growth and have primary roles in endochondral ossification. It also leads to the formation of permanent cartilaginous tissues that provide major structural support in the articular joints and respiratory and auditory tracts throughout life. Defects in chondrogenesis cause chondrodysostoses and chondrodysplasias. These skeletal malformation diseases account for a significant proportion of birth defects in humans and can dramatically affect a person's expectancy and quality of life. Chondrogenesis occurs when pluripotent mesenchymal cells commit to the chondrocyte lineage, and through a series of differentiation steps build and eventually remodel cartilage. This review summarizes and discusses our current knowledge and lack of knowledge about the chondrocyte differentiation pathway, from mesenchymal cells to growth plate and articular chondrocytes, with a main focus on how it is controlled by tissue patterning and cell differentiation transcription factors, such as, but not limited to, Pax1 and Pax9, Nkx3.1 and Nkx3.2, Sox9, Sox5 and Sox6, Runx2 and Runx3, and c‐Maf. Birth Defects Research (Part C) 75:200–212, 2005. © 2005 Wiley‐Liss, Inc.
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Cites
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Cited by
The Role of Hypoxia in Development of the Mammalian Embryo
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535 East 70th Street, C. R. B., Goldring, M., Otero, M., Plumb, D., Dragomir, C., Favero, M., EI Hachem, K., Hashimoto, K., Roach, H., Olivotto, E., et al. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a16 · Cited by 489
Cartilage engineering: a crucial combination of cells, biomaterials and biofactors
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Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures
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Goldring, M. B. (2012) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x12448454 · Cited by 444
Metadata
- Authors
- Lefebvre, V., & Smits, P.
- Venue
- Birth Defects Research Part C: Embryo Today: Reviews
- Publisher
- Wiley
- Published
- 2005-09
- Volume
- 75
- Issue
- 3
- Pages
- 200-212
- ISSN
- 1542-975X (ISSN-L)
- 1542-9768
- OpenAlex
- W1983529894
- Cited by
- 476
- References
- 75
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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