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Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
Open accessAbstract
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase. Previously, we have demonstrated that MKlp2 recruits Polo-like kinase 1 (Plk1) to the central spindle in anaphase. We now find that in MKlp2 but not MKlp1-depleted cells the Aurora B–INCENP complex remains at the centromeres and fails to relocate to the central spindle. MKlp2 exerts dual control over Aurora B localization, because it is a binding partner for Aurora B, and furthermore for the phosphatase Cdc14A. Cdc14A can dephosphorylate INCENP and may contribute to its relocation to the central spindle in anaphase. We propose that MKlp2 is involved in the localization of Plk1, Aurora B, and Cdc14A to the central spindle during anaphase, and that the integration of signaling by these proteins is necessary for proper cytokinesis.
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Cited by
Shared and separate functions of polo-like kinases and aurora kinases in cancer
Lens, S. M. A., Voest, E. E., & Medema, R. H. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2964 · Cited by 597
Nuclear envelope assembly defects link mitotic errors to chromothripsis
Liu, S., Kwon, M., Mannino, M., Yang, N., Renda, F., Khodjakov, A., & Pellman, D. (2018) · Nature · doi:10.1038/s41586-018-0534-z · Cited by 314
The chromosomal passenger complex: guiding Aurora-B through mitosis
Vader, G., Medema, R. H., & Lens, S. M. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604032 · Cited by 299
Cytokinetic Abscission: Molecular Mechanisms and Temporal Control
Mierzwa, B., & Gerlich, D. W. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.006 · Cited by 288
Mechanism and regulation of kinesin motors.
Yildiz, A. (2025) · Nature reviews. Molecular cell biology · doi:10.1038/s41580-024-00780-6 · Cited by 88
Metadata
- Authors
- Gruneberg, U., Neef, R., Honda, R., Nigg, E. A., & Barr, F. A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-07-19
- Volume
- 166
- Issue
- 2
- Pages
- 167-172
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2125247503
- Cited by
- 326
- References
- 0
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gruneberg, U., Neef, R., Honda, R., Nigg, E. A., & Barr, F. A. (2004). Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200403084
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