The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation
Open accessAbstract
The epidermal growth factor (EGF)–induced increase in free barbed ends, resulting in actin polymerization at the leading edge of the lamellipodium in carcinoma cells, occurs as two transients: an early one at 1 min and a late one at 3 min. Our results reveal that phospholipase (PLC) is required for triggering the early barbed end transient. Phosphoinositide-3 kinase selectively regulates the late barbed end transient. Inhibition of PLC inhibits cofilin activity in cells during the early transient, delays the initiation of protrusions, and inhibits the ability of cells to sense a gradient of EGF. Suppression of cofilin, using either small interfering RNA silencing or function-blocking antibodies, selectively inhibits the early transient. Therefore, our results demonstrate that the early PLC and cofilin-dependent barbed end transient is required for the initiation of protrusions and is involved in setting the direction of cell movement in response to EGF.
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Cites
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Takenawa, T., & Miki, H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.10.1801 · Cited by 604
Cited by
Wang, W., Goswami, S., Lapidus, K., Wells, A. L., Wyckoff, J. B., Sahai, E., Singer, R. H., Segall, J. E., & Condeelis, J. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1136 · Cited by 455
Self-citationPhosphoinositide signalling in cancer: beyond PI3K and PTEN
Bunney, T. D., & Katan, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2842 · Cited by 400
Ins and outs of ADF/cofilin activity and regulation
Van Troys, M., Huyck, L., Leyman, S., Dhaese, S., Vandekerkhove, J., & Ampe, C. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.04.001 · Cited by 329
Phospholipase signalling networks in cancer
Park, J. B., Lee, C. S., Jang, J.-H., Ghim, J., Kim, Y.-J., You, S., Hwang, D., Suh, P.-G., & Ryu, S. H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3379 · Cited by 276
Tumor cells caught in the act of invading: their strategy for enhanced cell motility
Wang, W., Goswami, S., Sahai, E., Wyckoff, J. B., Segall, J. E., & Condeelis, J. S. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.01.003 · Cited by 274
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Metadata
- Authors
- Mouneimne, G., Soon, L., DesMarais, V., Sidani, M., Song, X., Yip, S.-C., Ghosh, M., Eddy, R., Backer, J. M., & Condeelis, J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-08-30
- Volume
- 166
- Issue
- 5
- Pages
- 697-708
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2172048983
- Cited by
- 225
- References
- 2
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Mouneimne, G., Soon, L., DesMarais, V., Sidani, M., Song, X., Yip, S.-C., Ghosh, M., Eddy, R., Backer, J. M., & Condeelis, J. (2004). Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200405156
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