The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes
Open accessAbstract
Tip growth in neuronal cells, plant cells, and fungal hyphae is known to require tip-localized Rho GTPase, calcium, and filamentous actin (F-actin), but how they interact with each other is unclear. The pollen tube is an exciting model to study spatiotemporal regulation of tip growth and F-actin dynamics. An Arabidopsis thaliana Rho family GTPase, ROP1, controls pollen tube growth by regulating apical F-actin dynamics. This paper shows that ROP1 activates two counteracting pathways involving the direct targets of tip-localized ROP1: RIC3 and RIC4. RIC4 promotes F-actin assembly, whereas RIC3 activates Ca2+ signaling that leads to F-actin disassembly. Overproduction or depletion of either RIC4 or RIC3 causes tip growth defects that are rescued by overproduction or depletion of RIC3 or RIC4, respectively. Thus, ROP1 controls actin dynamics and tip growth through a check and balance between the two pathways. The dual and antagonistic roles of this GTPase may provide a unifying mechanism by which Rho modulates various processes dependent on actin dynamics in eukaryotic cells.
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Cites
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Cited by
The Cytoskeleton and Its Regulation by Calcium and Protons
Hepler, P. K. (2016) · Plant Physiology · doi:10.1104/pp.15.01506 · Cited by 133
Ruan, J., Lai, L., Ou, H., & Yi, P. (2023) · Nature Communications · doi:10.1038/s41467-023-42879-y · Cited by 23
Metadata
- Authors
- Gu, Y., Fu, Y., Dowd, P., Li, S., Vernoud, V., Gilroy, S., & Yang, Z.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-04-11
- Volume
- 169
- Issue
- 1
- Pages
- 127-138
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2116694451
- Cited by
- 340
- References
- 1
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. https://app.cochat.ai/papers/10.1083/jcb.200409140
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- Gu, Y., Fu, Y., Dowd, P., Li, S., Vernoud, V., Gilroy, S., & Yang, Z. (2005). A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200409140
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