The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
Open accessAbstract
Cell polarization is essential in a wide range of biological processes such as morphogenesis, asymmetric division, and directed migration. In this study, we show that two tumor suppressor proteins, adenomatous polyposis coli (APC) and Dlg1-SAP97, are required for the polarization of migrating astrocytes. Activation of the Par6–PKCζ complex by Cdc42 at the leading edge of migrating cells promotes both the localized association of APC with microtubule plus ends and the assembly of Dlg-containing puncta in the plasma membrane. Biochemical analysis and total internal reflection fluorescence microscopy reveal that the subsequent physical interaction between APC and Dlg1 is required for polarization of the microtubule cytoskeleton.
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Citations
Cites
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Etienne-Manneville, S., & Hall, A. (2003) · Nature · doi:10.1038/nature01423 · Cited by 835
Self-citation
Cited by
WNT signalling pathways as therapeutic targets in cancer
Anastas, J. N., & Moon, R. T. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3419 · Cited by 1,911
Tracking the ends: a dynamic protein network controls the fate of microtubule tips
Akhmanova, A., & Steinmetz, M. O. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2369 · Cited by 1,047
The PAR Proteins: Fundamental Players in Animal Cell Polarization
Goldstein, B., & Macara, I. G. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.10.007 · Cited by 758
Microtubules in Cell Migration
Etienne-Manneville, S. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155711 · Cited by 508
Self-citationPKC and the control of localized signal dynamics
Rosse, C., Linch, M., Kermorgant, S., Cameron, A. J. M., Boeckeler, K., & Parker, P. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2847 · Cited by 477
Metadata
- Authors
- Etienne-Manneville, S., Manneville, J.-B., Nicholls, S., Ferenczi, M. A., & Hall, A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-09-12
- Volume
- 170
- Issue
- 6
- Pages
- 895-901
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2092619797
- Cited by
- 297
- References
- 2
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Etienne-Manneville, S., Manneville, J.-B., Nicholls, S., Ferenczi, M. A., & Hall, A. (2005). Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200412172
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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