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A microtubule-dependent zone of active RhoA during cleavage plane specification
Open accessAbstract
Cytokinesis in animal cells results from the assembly and constriction of a circumferential array of actin filaments and myosin-2. Microtubules of the mitotic apparatus determine the position at which the cytokinetic actomyosin array forms, but the molecular mechanisms by which they do so remain unknown. The small GTPase RhoA has previously been implicated in cytokinesis. Using four-dimensional microscopy and a probe for active RhoA, we show that active RhoA concentrates in a precisely bounded zone before cytokinesis and is independent of actin assembly. Cytokinetic RhoA activity zones are common to four echinoderm species, the vertebrate Xenopus laevis, and the highly asymmetric cytokinesis accompanying meiosis. Microtubules direct the formation and placement of the RhoA activity zone, and the zone is repositioned after physical spindle displacement. We conclude that microtubules specify the cytokinetic apparatus via a dynamic zone of local RhoA activity.
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Citations
Cited by
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Caswell, P. T., Vadrevu, S., & Norman, J. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2799 · Cited by 460
Cytokinesis: Welcome to the Rho zone
Piekny, A., Werner, M., & Glotzer, M. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.10.006 · Cited by 365
Understanding cytokinesis: lessons from fission yeast
Pollard, T. D., & Wu, J.-Q. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2834 · Cited by 317
Cytokinetic Abscission: Molecular Mechanisms and Temporal Control
Mierzwa, B., & Gerlich, D. W. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.006 · Cited by 288
Liver tetraploidization is controlled by a new process of incomplete cytokinesis
Margall-Ducos, G., Celton-Morizur, S., Couton, D., Brégerie, O., & Desdouets, C. (2007) · Journal of Cell Science · doi:10.1242/jcs.016907 · Cited by 170
Metadata
- Authors
- Bement, W. M., Benink, H. A., & von Dassow, G.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-07-04
- Volume
- 170
- Issue
- 1
- Pages
- 91-101
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2161614836
- Cited by
- 339
- References
- 0
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bement, W. M., Benink, H. A., & von Dassow, G. (2005). A microtubule-dependent zone of active RhoA during cleavage plane specification. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200501131
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