The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling
Open accessAbstract
Protein degradation, chromatin remodeling, and membrane trafficking are critically regulated by ubiquitylation. The presence of several coexisting ubiquitin-dependent processes, each of crucial importance to the cell, is remarkable. This brings up questions on how the usage of this versatile regulator is negotiated between the different cellular processes. During proteotoxic stress, the accumulation of ubiquitylated substrates coincides with the depletion of ubiquitylated histone H2A and chromatin remodeling. We show that this redistribution of ubiquitin during proteotoxic stress is a direct consequence of competition for the limited pool of free ubiquitin. Thus, the ubiquitin cycle couples various ubiquitin-dependent processes because of a rate-limiting pool of free ubiquitin. We propose that this ubiquitin equilibrium may allow cells to sense proteotoxic stress in a genome-wide fashion.
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Cited by
Tavares, L., Dimitrova, E., Oxley, D., Webster, J., Poot, R., Demmers, J., Bezstarosti, K., Taylor, S., Ura, H., Koide, H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.029 · Cited by 555
Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis
Dasuri, K., Zhang, L., & Keller, J. N. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.016 · Cited by 371
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357
BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair
Ismail, I. H., Andrin, C., McDonald, D., & Hendzel, M. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003034 · Cited by 255
DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks
Pankotai, T., Bonhomme, C., Chen, D., & Soutoglou, E. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2224 · Cited by 239
Metadata
- Authors
- Dantuma, N. P., Groothuis, T. A. M., Salomons, F. A., & Neefjes, J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-04-10
- Volume
- 173
- Issue
- 1
- Pages
- 19-26
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2148143293
- Cited by
- 265
- References
- 20
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Dantuma, N. P., Groothuis, T. A. M., Salomons, F. A., & Neefjes, J. (2006). A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200510071
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
