The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth
Open accessAbstract
Cilia are specialized organelles that play an important role in several biological processes, including mechanosensation, photoperception, and osmosignaling. Mutations in proteins localized to cilia have been implicated in a growing number of human diseases. In this study, we demonstrate that the von Hippel-Lindau (VHL) protein (pVHL) is a ciliary protein that controls ciliogenesis in kidney cells. Knockdown of pVHL impeded the formation of cilia in mouse inner medullary collecting duct 3 kidney cells, whereas the expression of pVHL in VHL-negative renal cancer cells rescued the ciliogenesis defect. Using green fluorescent protein–tagged end-binding protein 1 to label microtubule plus ends, we found that pVHL does not affect the microtubule growth rate but is needed to orient the growth of microtubules toward the cell periphery, a prerequisite for the formation of cilia. Furthermore, pVHL interacts with the Par3–Par6–atypical PKC complex, suggesting a mechanism for linking polarity pathways to microtubule capture and ciliogenesis.
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Cites
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
Mutations of the VHL tumour suppressor gene in renal carcinoma
Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., Duh, F.-M., et al. (1994) · Nature Genetics · doi:10.1038/ng0594-85 · Cited by 1,730
Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Etienne-Manneville, S., & Hall, A. (2003) · Nature · doi:10.1038/nature01423 · Cited by 835
The von Hippel-Lindau gene, kidney cancer, and oxygen sensing.
Kaelin, W. G. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000092803.69761.41 · Cited by 135
Cited by
When cilia go bad: cilia defects and ciliopathies
Fliegauf, M., Benzing, T., & Omran, H. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2278 · Cited by 1,257
Self-citationHypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
Schödel, J., Grampp, S., Maher, E. R., Moch, H., Ratcliffe, P. J., Russo, P., & Mole, D. R. (2016) · European Urology · doi:10.1016/j.eururo.2015.08.007 · Cited by 405
VHL and HIF signalling in renal cell carcinogenesis
Baldewijns, M. M., van Vlodrop, I. J., Vermeulen, P. B., Soetekouw, P. M., van Engeland, M., & de Bruïne, A. P. (2010) · The Journal of Pathology · doi:10.1002/path.2689 · Cited by 316
Polarity proteins in migration and invasion
Etienne-Manneville, S. (2008) · Oncogene · doi:10.1038/onc.2008.347 · Cited by 295
The VHL tumor suppressor: master regulator of HIF
Haase, V. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789649394 · Cited by 175
Metadata
- Authors
- Schermer, B., Ghenoiu, C., Bartram, M., Müller, R. U., Kotsis, F., Höhne, M., Kühn, W., Rapka, M., Nitschke, R., Zentgraf, H., Fliegauf, M., Omran, H., Walz, G., & Benzing, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-11-13
- Volume
- 175
- Issue
- 4
- Pages
- 547-554
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2161216917
- Cited by
- 174
- References
- 5
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. https://app.cochat.ai/papers/10.1083/jcb.200605092
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- Schermer, B., Ghenoiu, C., Bartram, M., Müller, R. U., Kotsis, F., Höhne, M., Kühn, W., Rapka, M., Nitschke, R., Zentgraf, H., Fliegauf, M., Omran, H., Walz, G., & Benzing, T. (2006). The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200605092
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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