RHO GTPASES: Biochemistry and Biology

Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity

Shi, S.-H., Jan, L. Y., & Jan, Y.-N. (2003) · Cell · doi:10.1016/s0092-8674(02)01249-7 · Cited by 600 · see citing works

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.

Schwamborn, J. C., & Püschel, A. W. (2004) · Nature Neuroscience · doi:10.1038/nn1295 · Cited by 385 · see citing works

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

Takeya, R., Ueno, N., Kami, K., Taura, M., Kohjima, M., Izaki, T., Nunoi, H., & Sumimoto, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212856200 · Cited by 380 · see citing works

PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex

Yamanaka, T., Horikoshi, Y., Suzuki, A., Sugiyama, Y., Kitamura, K., Maniwa, R., Nagai, Y., Yamashita, A., Hirose, T., Ishikawa, H., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00453.x · Cited by 306 · see citing works

A landscape of driver mutations in melanoma

Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610 · see citing works

Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206 · see citing works

Shaping cups into phagosomes and macropinosomes

Swanson, J. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2447 · Cited by 941 · see citing works

Activation of Platelet Function Through G Protein–Coupled Receptors

Offermanns, S. (2006) · Circulation Research · doi:10.1161/01.res.0000251742.71301.16 · Cited by 725 · see citing works

Branching out: mechanisms of dendritic arborization

Jan, Y.-N., & Jan, L. Y. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2836 · Cited by 693 · see citing works

Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K. S., Testori, A., Larue, L., & Goding, C. R. (2006) · Genes & Development · doi:10.1101/gad.406406 · Cited by 608 · see citing works

Tumour-associated mutant p53 drives the Warburg effect

Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., Lin, M., Yu, H., Liu, L., Levine, A. J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3935 · Cited by 434 · see citing works

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

Cook, D. R., Rossman, K. L., & Der, C. J. (2014) · Oncogene · doi:10.1038/onc.2013.362 · Cited by 378 · see citing works

The Conserved GTPase Gem1 Regulates Endoplasmic Reticulum–Mitochondria Connections

Kornmann, B., Osman, C., & Walter, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111314108 · Cited by 335 · see citing works

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases

Shutes, A., Onesto, C., Picard, V., Leblond, B., Schweighoffer, F., & Der, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703571200 · Cited by 336 · see citing works

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double‐blind, randomised, controlled trial

Paulsen, G., Cumming, K. T., Holden, G., Hallén, J., Rønnestad, B. R., Sveen, O., Skaug, A., Paur, I., Bastani, N. E., Østgaard, H. N., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.267419 · Cited by 333 · see citing works

Cell-matrix interactions in dermal repair and scarring

Eckes, B., Nischt, R., & Krieg, T. (2010) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-3-4 · Cited by 205 · see citing works

ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65

Bisel, B., Wang, Y., Wei, J.-H., Xiang, Y., Tang, D., Miron-Mendoza, M., Yoshimura, S.-I., Nakamura, N., & Seemann, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805045 · Cited by 184 · see citing works

Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells

Pattabiraman, P. P., & Rao, P. V. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00317.2009 · Cited by 189 · see citing works

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

Ahmed, S., Bradshaw, A.-D., Gera, S., Dewan, M., & Xu, R. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6010005 · Cited by 174 · see citing works

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

Weber, M., Treanor, B., Depoil, D., Shinohara, H., Harwood, N. E., Hikida, M., Kurosaki, T., & Batista, F. D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072619 · Cited by 170 · see citing works

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

Huang, Z., Sutton, S. E., Wallenfang, A. J., Orchard, R. C., Wu, X., Feng, Y., Chai, J., & Alto, N. M. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1647 · Cited by 139 · see citing works

Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., Franklin, R. J. M., Brakebusch, C., Suter, U., & Relvas, J. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2158-06.2006 · Cited by 142 · see citing works

Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor

Yang, J., Zhang, Z., Roe, S. M., Marshall, C. J., & Barford, D. (2009) · Science · doi:10.1126/science.1174468 · Cited by 123 · see citing works

Mitosis can drive cell cannibalism through entosis

Durgan, J., Tseng, Y.-Y., Hamann, J. C., Domart, M.-C., Collinson, L., Hall, A., Overholtzer, M., & Florey, O. (2017) · eLife · doi:10.7554/elife.27134 · Cited by 117 · see citing works

The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2

Valnegri, P., Montrasio, C., Brambilla, D., Ko, J., Passafaro, M., & Sala, C. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr418 · Cited by 116 · see citing works

TOR kinase complexes and cell migration

Liu, L., & Parent, C. A. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102090 · Cited by 87 · see citing works

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

Leemhuis, J., Bouché, E., Frotscher, M., Henle, F., Hein, L., Herz, J., Meyer, D. K., Pichler, M., Roth, G., Schwan, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4036-10.2010 · Cited by 80 · see citing works

AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade

Kang, M.-G., Guo, Y., & Huganir, R. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812861106 · Cited by 82 · see citing works

NOD-like receptors in intestinal homeostasis and epithelial tissue repair

Parlato, M., & Yeretssian, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069594 · Cited by 79 · see citing works

Inversin/Nephrocystin-2 Is Required for Fibroblast Polarity and Directional Cell Migration

Veland, I. R., Montjean, R., Eley, L., Pedersen, L. B., Schwab, A., Goodship, J., Kristiansen, K., Pedersen, S. F., Saunier, S., & Christensen, S. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060193 · Cited by 67 · see citing works

Two Distinct Integrin-Mediated Mechanisms Contribute to Apical Lumen Formation in Epithelial Cells

Myllymäki, S. M., Teräväinen, T. P., & Manninen, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019453 · Cited by 64 · see citing works

Rho GTPases in neurodegeneration diseases

DeGeer, J., & Lamarche-Vane, N. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.06.016 · Cited by 46 · see citing works

<scp>RhoA</scp> regulation in space and time

de Seze, J., Gatin, J., & Coppey, M. (2023) · FEBS Letters · doi:10.1002/1873-3468.14578 · Cited by 42 · see citing works

Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization

Moreiras, H., Bento‐Lopes, L., Neto, M. V., Escrevente, C., Cabaço, L. C., Hall, M. J., Ramalho, J. S., Seabra, M. C., & Barral, D. C. (2022) · Traffic · doi:10.1111/tra.12843 · Cited by 34 · see citing works

Regulation of the endothelial barrier function: a filum granum of cellular forces, Rho-GTPase signaling and microenvironment

Amado-Azevedo, J., Valent, E. T., & Van Nieuw Amerongen, G. P. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1828-6 · Cited by 36 · see citing works

Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors

Kwofie, M. A., & Skowronski, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705170200 · Cited by 36 · see citing works

Cyasterone accelerates fracture healing by promoting MSCs migration and osteogenesis

Zhu, J., Liu, Y., Chen, C., Chen, H., Huang, J., Luo, Y., Zhao, K., Chen, D., Xu, Z., Li, W., et al. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.11.004 · Cited by 33 · see citing works

Cell Type-dependent HIF1 α-mediated Effects of Hypoxia on Proliferation, Migration and Metastatic Potential of Human Tumor Cells

Tátrai, E., Bartal, A., Gacs, A., Paku, S., Kenessey, I., Garay, T., Hegedűs, B., Molnár, E., Cserepes, M. T., Hegedűs, Z., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17806 · Cited by 33 · see citing works

The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling

Hendrick, J., Franz-Wachtel, M., Moeller, Y., Schmid, S., Macek, B., & Olayioye, M. A. (2016) · Journal of Cell Science · doi:10.1242/jcs.190074 · Cited by 32 · see citing works

Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors

Wardecki, T., Werner, P., Thomas, M., Templin, M. F., Schmidt, G., Brandner, J. M., & Merfort, I. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00027 · Cited by 23 · see citing works

Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects

Espinha, G., Osaki, J. H., Costa, E. T., & Forti, F. L. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2696952 · Cited by 21 · see citing works

Interplay of PKA and Rac: Fine-tuning of Rac localization and signaling

Bachmann, V. A., Bister, K., & Stefan, E. (2013) · Small GTPases · doi:10.4161/sgtp.27281 · Cited by 14 · see citing works

Ghost Neuron preparation unlocks high-resolution structural mapping of intracellular architecture in axons

Bodakuntla, S., Marelli, J., Vasquez-Montes, V., Glauser, S., Biertümpfel, C., & Mizuno, N. (2026) · Nature Communications · doi:10.1038/s41467-026-77741-4