The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices
Open accessAbstract
In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. In this study, we show that p53 deficiency in mouse embryonic fibroblasts cultured in three-dimensional matrices induces a switch from an elongated spindle morphology to a markedly spherical and flexible one associated with highly dynamic membrane blebs. These rounded, motile cells exhibit amoeboid-like movement and have considerably increased invasive properties. The morphological transition requires the RhoA–ROCK (Rho-associated coil-containing protein kinase) pathway and is prevented by RhoE. A similar p53-mediated transition is observed in melanoma A375P cancer cells. Our data suggest that genetic alterations of p53 in tumors are sufficient to promote motility and invasion, thereby contributing to metastasis.
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Cites
Taking Cell-Matrix Adhesions to the Third Dimension
Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
Collagen as a double-edged sword in tumor progression
Fang, M., Yuan, J., Peng, C., & Li, Y. (2014) · Tumor Biology · doi:10.1007/s13277-013-1511-7 · Cited by 580
p53 and its mutants in tumor cell migration and invasion
Muller, P. A. J., Vousden, K. H., & Norman, J. C. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009059 · Cited by 463
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
Kim, N. H., Kim, H. S., Li, X.-Y., Lee, I., Choi, H.-S., Kang, S. E., Cha, S. Y., Ryu, J. K., Yoon, D., Fearon, E. R., et al. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201103097 · Cited by 432
Delaloy, C., Liu, L., Lee, J.-A., Su, H., Shen, F., Yang, G.-Y., Young, W. L., Ivey, K. N., & Gao, F.-B. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.02.015 · Cited by 325
Metadata
- Authors
- Gadea, G., de Toledo, M., Anguille, C., & Roux, P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-07-02
- Volume
- 178
- Issue
- 1
- Pages
- 23-30
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2135737620
- Cited by
- 244
- References
- 1
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gadea, G., de Toledo, M., Anguille, C., & Roux, P. (2007). Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200701120
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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