p53 and its mutants in tumor cell migration and invasion
Open accessAbstract
In about half of all human cancers, the tumor suppressor p53 protein is either lost or mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 protein. Loss of p53 function is well known to influence cell cycle checkpoint controls and apoptosis. But it is now clear that p53 regulates other key stages of metastatic progression, such as cell migration and invasion. Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function.
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GOF mut-p53 exhibits interactions with distinct transcription factors (e.g., NF-ɣ, SREBP, VDR, Sp1, ETS2, NFR2, p73, p63) that promote tumor initiation and progression.
“In contrast to wt-p53, GOF mut-p53 exhibits interactions with distinct transcription factors (e.g., NF-ɣ, SREBP, VDR, Sp1, ETS2, NFR2, p73, p63) that promote tumor initiation and progression [13,72,73,74,75,76,77].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [72]
The “Mechanisms of mutant p53’s gain of function” section says mutant p53 interacts with the transcription factors p63 and p73 and negatively regulates their function. The Introduction links interference with p63 to tumor-cell migration and metastasis. Our copy does not substantiate the other listed transcription-factor interactions, so it supports only part of the attributed claim; no page numbers are available in the indexed passages. (LLM, conf=0.86)
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Alexandrova, A. Y., Ivanov, A. V., Chumakov, P. M., Kopnin, B. P., & Vasiliev, J. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203944 · Cited by 50 · see citing works
p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck
Gu, X., Coates, P. J., Boldrup, L., & Nylander, K. (2008) · Cancer Letters · doi:10.1016/j.canlet.2007.12.011 · Cited by 49 · see citing works
Tumor Suppressor p53 and Its Homologue p73α Affect Cell Migration
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Downregulation of Dicer enhances tumor cell proliferation and invasion
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The RhoA GEF Syx Is a Target of Rnd3 and Regulated via a Raf1-Like Ubiquitin-Related Domain
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Exploring the Gain of Function Contribution of AKT to Mammary Tumorigenesis in Mouse Models
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P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
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Self-citationRecurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma
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The p53 Pathway in Glioblastoma
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Tumour-associated mutant p53 drives the Warburg effect
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Molecular Pathogenesis of Pancreatic Cancer
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Links between mutant p53 and genomic instability
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- Authors
- Muller, P. A. J., Vousden, K. H., & Norman, J. C.
- Affiliations
- Cancer Research UK Scotland Institute (GB)
- Corresponding author
- Muller, Patricia A. J.
- Norman, Jim C.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2011-01-24
- Volume
- 192
- Issue
- 2
- Pages
- 209-218
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC3172183
- OpenAlex
- W2005155951
- Cited by
- 463
- References
- 101
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 12 · 2023: 19 · 2022: 24 · 2021: 34 · 2020: 25 · 2019: 28 · 2018: 28 · 2017: 28 · 2016: 39 · 2015: 30 · 2014: 54 · 2013: 55 · 2012: 41
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Funders
- Cancer Research UK
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- p53, mutant p53, tumor cell migration, tumor invasion, metastasis, p63, tumor suppressor, cell cycle checkpoints, apoptosis
- MeSH terms
- Animals, Cell Movement, Humans, Neoplasm Invasiveness, Neoplasms, Tumor Suppressor Protein p53, Mutant Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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