The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Zinc is a novel intracellular second messenger
Open accessAbstract
Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated. Although zinc affects several signaling molecules and may act as a neurotransmitter, it remains unknown whether zinc acts as an intracellular second messenger capable of transducing extracellular stimuli into intracellular signaling events. In this study, we report that the cross-linking of the high affinity immunoglobin E receptor (Fcε receptor I [FcεRI]) induced a release of free zinc from the perinuclear area, including the endoplasmic reticulum in mast cells, a phenomenon we call the zinc wave. The zinc wave was dependent on calcium influx and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase activation. The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcεRI-mediated signaling. Collectively, our findings indicate that zinc is a novel intracellular second messenger.
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Cites
Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function
Hashimoto, A., Takeda, K., Inaba, M., Sekimata, M., Kaisho, T., Ikehara, S., Homma, Y., Akira, S., & Kurosaki, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1738 · Cited by 155
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Cited by
Kambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158
Zinc biochemistry: From a single zinc enzyme to a key element of life
Maret, W. (2013) · Advances in Nutrition · doi:10.3945/an.112.003038 · Cited by 818
Zinc and its role in immunity and inflammation
Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798
Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420
Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages
Botella, H., Peyron, P., Levillain, F., Poincloux, R., Poquet, Y., Brandli, I., Wang, C., Tailleux, L., Tilleul, S., Charrière, G. M., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.08.006 · Cited by 381
Metadata
- Authors
- Yamasaki, S., Sakata-Sogawa, K., Hasegawa, A., Suzuki, T., Kabu, K., Sato, E., Kurosaki, T., Yamashita, S., Tokunaga, M., Nishida, K., & Hirano, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-05-14
- Volume
- 177
- Issue
- 4
- Pages
- 637-645
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2164258188
- Cited by
- 592
- References
- 1
- FWCI
- 22.05
- Type
- journal article
- Language
- en
- Open access
- green
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