The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cep164, a novel centriole appendage protein required for primary cilium formation
Open accessAbstract
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and severe diseases. The basal body that functions in PC assembly is derived from the mature centriole, a component of the centrosome. Through a small interfering RNA screen we found several centrosomal proteins (Ceps) to be involved in PC formation. One newly identified protein, Cep164, was indispensable for PC formation and hence characterized in detail. By immunogold electron microscopy, Cep164 could be localized to the distal appendages of mature centrioles. In contrast to ninein and Cep170, two components of subdistal appendages, Cep164 persisted at centrioles throughout mitosis. Moreover, the localizations of Cep164 and ninein/Cep170 were mutually independent during interphase. These data implicate distal appendages in PC formation and identify Cep164 as an excellent marker for these structures.
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Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384
Proteomic characterization of the human centrosome by protein correlation profiling
Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., & Mann, M. (2003) · Nature · doi:10.1038/nature02166 · Cited by 1,319
Self-citationOverview of Structure and Function of Mammalian Cilia
Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142 · cited 2×
“Thus, with few exceptions, PC are nonmotile and instead function as sensory organelles (Pazour and Witman, 2003; Singla and Reiter, 2006; Satir and Christensen, 2007).”
BackgroundA motility in the eukaryotic flagellum unrelated to flagellar beating.
Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007
HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium
Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P., & Golemis, E. A. (2007) · Cell · doi:10.1016/j.cell.2007.04.035 · Cited by 890
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A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface
Gupta, G. D., Coyaud, É., Gonçalves, J., Mojarad, B. A., Liu, Y., Wu, Q., Gheiratmand, L., Comartin, D., Tkach, J. M., Cheung, S. W. T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.065 · Cited by 538
Chapter Two Intraflagellar Transport (IFT)
Pedersen, L. B., & Rosenbaum, J. L. (2008) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00802-8 · Cited by 521
Centriole distal appendages promote membrane docking, leading to cilia initiation
Tanos, B. E., Yang, H.-J., Soni, R., Wang, W.-J., Macaluso, F. P., Asara, J. M., & Tsou, M.-F. B. (2013) · Genes & Development · doi:10.1101/gad.207043.112 · Cited by 417
Craige, B., Tsao, C.-C., Diener, D. R., Hou, Y., Lechtreck, K.-F., Rosenbaum, J. L., & Witman, G. B. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006105 · Cited by 386
ATR signalling: more than meeting at the fork
Nam, E. A., & Cortez, D. (2011) · Biochemical Journal · doi:10.1042/bj20102162 · Cited by 316
Metadata
- Authors
- Graser, S., Stierhof, Y.-D., Lavoie, S. B., Gassner, O. S., Lamla, S., Le Clech, M., & Nigg, E. A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-10-22
- Volume
- 179
- Issue
- 2
- Pages
- 321-330
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2169449091
- Cited by
- 516
- References
- 5
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Graser, S., Stierhof, Y.-D., Lavoie, S. B., Gassner, O. S., Lamla, S., Le Clech, M., & Nigg, E. A. (2007). Cep164, a novel centriole appendage protein required for primary cilium formation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200707181
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