The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Regulation of ROS signal transduction by NADPH oxidase 4 localization
Open accessAbstract
Reactive oxygen species (ROS) function as intracellular signaling molecules in a diverse range of biological processes. However, it is unclear how freely diffusible ROS dictate specific cellular responses. In this study, we demonstrate that nicotinamide adenine dinucleotide phosphate reduced oxidase 4 (Nox4), a major Nox isoform expressed in nonphagocytic cells, including vascular endothelium, is localized to the endoplasmic reticulum (ER). ER localization of Nox4 is critical for the regulation of protein tyrosine phosphatase (PTP) 1B, also an ER resident, through redox-mediated signaling. Nox4-mediated oxidation and inactivation of PTP1B in the ER serves as a regulatory switch for epidermal growth factor (EGF) receptor trafficking and specifically acts to terminate EGF signaling. Consistent with this notion, PTP1B oxidation could also be modulated by ER targeting of antioxidant enzymes but not their untargeted counterparts. These data indicate that the specificity of intracellular ROS-mediated signal transduction may be modulated by the localization of Nox isoforms within specific subcellular compartments.
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Cites
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Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide
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Cited by
Cellular mechanisms and physiological consequences of redox-dependent signalling
Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093
Chemistry and biology of reactive oxygen species in signaling or stress responses
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Hydrogen peroxide sensing, signaling and regulation of transcription factors
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Nox proteins in signal transduction
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ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
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Metadata
- Authors
- Chen, K., Kirber, M. T., Xiao, H., Yang, Y., & Keaney, J. F.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2008-06-23
- Volume
- 181
- Issue
- 7
- Pages
- 1129-1139
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2008656776
- Cited by
- 468
- References
- 48
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chen, K., Kirber, M. T., Xiao, H., Yang, Y., & Keaney, J. F. (2008). Regulation of ROS signal transduction by NADPH oxidase 4 localization. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200709049
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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