Cited by 2,093Redox biology and oxidative stressAntioxidant Activity and Oxidative StressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, Kira M., Finkel, Toren·2014·Nature Reviews Molecular Cell Biology

Abstract

Reactive oxygen species (ROS), which were originally characterized in terms of their harmful effects on cells and invading microorganisms, are increasingly implicated in various cell fate decisions and signal transduction pathways. The mechanism involved in ROS-dependent signalling involves the reversible oxidation and reduction of specific amino acids, with crucial reactive Cys residues being the most frequent target. In this Review, we discuss the sources of ROS within cells and what is known regarding how intracellular oxidant levels are regulated. We further discuss the recent observations that reduction-oxidation (redox)-dependent regulation has a crucial role in an ever-widening range of biological activities - from immune function to stem cell self-renewal, and from tumorigenesis to ageing.

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Crossref · 10.1038/nrm3801

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  • CAFs promote cancer growth and invasiveness, and both CAFs and ROS are linked through increases in ROS-generated CAFs to which most cancers respond by increasing expression of antioxidant genes.

    “CAFs can also promote cancer growth and invasiveness, and both CAFS and ROS are linked through the increases in ROS-generated CAFs to which most cancers respond by increasing the expression of antioxidant genes52–54”

    From ROS in cancer therapy: the bright side of the moon (2020) · cites this paper as [54]

  • The NADPH oxidase system is an important source of intracellular ROS and a key player in the generation of oxidative stress.

    “In addition to mitochondria, the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system has been identified as an important source of intracellular ROS and a key player in the generation of oxidative stress.”

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Authors
Holmström, K. M., & Finkel, T.
Affiliations
National Institutes of Health (US)
Corresponding author
Finkel, Toren
Venue
Nature Reviews Molecular Cell Biology
Published
2014-05-23
Volume
15
Issue
6
Pages
411-421
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2007636933
Cited by
2,093
References
121
Citations by year
2026: 128 · 2025: 154 · 2024: 192 · 2023: 175 · 2022: 174 · 2021: 212 · 2020: 195 · 2019: 163 · 2018: 207 · 2017: 192 · 2016: 152 · 2015: 114 · 2014: 32
FWCI
15.10
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fondation Leducq
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
reactive oxygen species, redox signaling, cysteine oxidation, protein oxidation, signal transduction, innate immunity, stem cell self-renewal, carcinogenesis, aging, metabolic regulation
MeSH terms
Aging, Animals, Cell Physiological Phenomena, Humans, Neoplasms, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species

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