The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g
Open accessAbstract
Crista junctions (CJs) are important for mitochondrial organization and function, but the molecular basis of their formation and architecture is obscure. We have identified and characterized a mitochondrial membrane protein in yeast, Fcj1 (formation of CJ protein 1), which is specifically enriched in CJs. Cells lacking Fcj1 lack CJs, exhibit concentric stacks of inner membrane in the mitochondrial matrix, and show increased levels of F1FO–ATP synthase (F1FO) supercomplexes. Overexpression of Fcj1 leads to increased CJ formation, branching of cristae, enlargement of CJ diameter, and reduced levels of F1FO supercomplexes. Impairment of F1FO oligomer formation by deletion of its subunits e/g (Su e/g) causes CJ diameter enlargement and reduction of cristae tip numbers and promotes cristae branching. Fcj1 and Su e/g genetically interact. We propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F1FO oligomeric state, thereby controlling membrane curvature of cristae to generate CJs and cristae tips.
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The cell biology of mitochondrial membrane dynamics
Giacomello, M., Pyakurel, A., Glytsou, C., & Scorrano, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0210-7 · Cited by 1,550
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Mitochondrial Cristae: Where Beauty Meets Functionality
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Metadata
- Authors
- Rabl, R., Soubannier, V., Scholz, R., Vogel, F., Mendl, N., Vasiljev-Neumeyer, A., Körner, C., Jagasia, R., Keil, T., Baumeister, W., Cyrklaff, M., Neupert, W., & Reichert, A. S.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2009-06-15
- Volume
- 185
- Issue
- 6
- Pages
- 1047-1063
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2100617050
- Cited by
- 306
- References
- 61
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rabl, R., Soubannier, V., Scholz, R., Vogel, F., Mendl, N., Vasiljev-Neumeyer, A., Körner, C., Jagasia, R., Keil, T., Baumeister, W., Cyrklaff, M., Neupert, W., & Reichert, A. S. (2009). Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. Journal of Cell Biology. https://doi.org/10.1083/jcb.200811099
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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