The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

Lechtreck, Karl-Ferdinand; Johnson, Eric C.; Sakai, Tsuyoshi; Cochran, Deborah; Ballif, Bryan A.; Rush, John; Pazour, Gregory J.; Ikebe, Mitsuo; Witman, George B.

doi:10.1083/jcb.200909183

The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

In humans, seven evolutionarily conserved genes that cause the cilia-related disorder Bardet-Biedl syndrome (BBS) encode proteins that form a complex termed the BBSome. The function of the BBSome in the cilium is not well understood. We purified a BBSome-like complex from Chlamydomonas reinhardti…