The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
αE-catenin regulates actin dynamics independently of cadherin-mediated cell–cell adhesion
Open accessAbstract
αE-catenin binds the cell–cell adhesion complex of E-cadherin and β-catenin (β-cat) and regulates filamentous actin (F-actin) dynamics. In vitro, binding of αE-catenin to the E-cadherin–β-cat complex lowers αE-catenin affinity for F-actin, and αE-catenin alone can bind F-actin and inhibit Arp2/3 complex–mediated actin polymerization. In cells, to test whether αE-catenin regulates actin dynamics independently of the cadherin complex, the cytosolic αE-catenin pool was sequestered to mitochondria without affecting overall levels of αE-catenin or the cadherin–catenin complex. Sequestering cytosolic αE-catenin to mitochondria alters lamellipodia architecture and increases membrane dynamics and cell migration without affecting cell–cell adhesion. In contrast, sequestration of cytosolic αE-catenin to the plasma membrane reduces membrane dynamics. These results demonstrate that the cytosolic pool of αE-catenin regulates actin dynamics independently of cell–cell adhesion.
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Cites
Itoh, M., Nagafuchi, A., Moroi, S., & Tsukita, S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.1.181 · Cited by 677
Ehrlich, J. S., Hansen, M. D. H., & Nelson, W. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00216-2 · Cited by 358
Self-citation
Cited by
The many faces and functions of β‐catenin
Valenta, T., Hausmann, G., & Basler, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.150 · Cited by 1,598
Borghi, N., Sorokina, M., Shcherbakova, O. G., Weis, W. I., Pruitt, B. L., Nelson, W. J., & Dunn, A. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204390109 · Cited by 591
Self-citationForce-dependent conformational switch of α-catenin controls vinculin binding
Yao, M., Qiu, W., Liu, R., Efremov, A. K., Cong, P., Seddiki, R., Payre, M., Lim, C. T., Ladoux, B., Mège, R.-M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5525 · Cited by 454
Niessen, C. M., Leckband, D., & Yap, A. S. (2011) · Physiological Reviews · doi:10.1152/physrev.00004.2010 · Cited by 427
Silvis, M. R., Kreger, B. T., Lien, W.-H., Klezovitch, O., Rudakova, G. M., Camargo, F. D., Lantz, D. M., Seykora, J. T., & Vasioukhin, V. (2011) · Science Signaling · doi:10.1126/scisignal.2001823 · Cited by 342
Metadata
- Authors
- Benjamin, J. M., Kwiatkowski, A. V., Yang, C., Korobova, F., Pokutta, S., Svitkina, T., Weis, W. I., & Nelson, W. J.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-04-19
- Volume
- 189
- Issue
- 2
- Pages
- 339-352
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2117030660
- Cited by
- 159
- References
- 2
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Benjamin, J. M., Kwiatkowski, A. V., Yang, C., Korobova, F., Pokutta, S., Svitkina, T., Weis, W. I., & Nelson, W. J. (2010). αE-catenin regulates actin dynamics independently of cadherin-mediated cell–cell adhesion. Journal of Cell Biology. https://doi.org/10.1083/jcb.200910041
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