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Cited by 427Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsDevelopmental Biology and Gene Regulation

Tissue Organization by Cadherin Adhesion Molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation

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Niessen, Carien M., Leckband, Deborah, Yap, Alpha S.·2011·Physiological Reviews
DOI 10.1152/physrev.00004.2010PMC PMC3556819
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Abstract

This review addresses the cellular and molecular mechanisms of cadherin-based tissue morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations of cells in organs and tissues. In metazoa, adhesion receptors of the classical cadherin family play important roles in establishing and maintaining such tissue organization. Indeed, it is apparent that cadherins participate in a range of morphogenetic events that range from support of tissue integrity to dynamic cellular rearrangements. A comprehensive understanding of cadherin-based morphogenesis must then define the molecular and cellular mechanisms that support these distinct cadherin biologies. Here we focus on four key mechanistic elements: the molecular basis for adhesion through cadherin ectodomains, the regulation of cadherin expression at the cell surface, cooperation between cadherins and the actin cytoskeleton, and regulation by cell signaling. We discuss current progress and outline issues for further research in these fields.

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Authors
Niessen, C. M., Leckband, D., & Yap, A. S.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Yap, Alpha S.
ORCID
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2011-04
Volume
91
Issue
2
Pages
691-731
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00004.2010
PMC
PMC3556819
OpenAlex
W2128494980
Cited by
427
References
6
Citations by year
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FWCI
4.33
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD059002)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
cadherins, tissue morphogenesis, cell adhesion, tissue organization, actin cytoskeleton, signal transduction, cell rearrangement, tissue integrity
MeSH terms
Animals, Cell Physiological Phenomena, Cytoskeleton, Humans, Receptors, Cell Surface, Signal Transduction, Cadherins

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