The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury
Open accessAbstract
Regenerative responses to axonal injury involve changes in gene expression; however, little is known about how such changes can be induced from a distant site of injury. In this study, we describe a nerve crush assay in Drosophila melanogaster to study injury signaling and regeneration mechanisms. We find that Wallenda (Wnd), a conserved mitogen-activated protein kinase (MAPK) kinase kinase homologous to dual leucine zipper kinase, functions as an upstream mediator of a cell-autonomous injury signaling cascade that involves the c-Jun NH2-terminal kinase MAPK and Fos transcription factor. Wnd is physically transported in axons, and axonal transport is required for the injury signaling mechanism. Wnd is regulated by a conserved E3 ubiquitin ligase, named Highwire (Hiw) in Drosophila. Injury induces a rapid increase in Wnd protein concomitantly with a decrease in Hiw protein. In hiw mutants, injury signaling is constitutively active, and neurons initiate a faster regenerative response. Our data suggest that the regulation of Wnd protein turnover by Hiw can function as a damage surveillance mechanism for responding to axonal injury.
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Self-citationRegulation of axonal regeneration after mammalian spinal cord injury
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
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Metadata
- Authors
- Xiong, X., Wang, X., Ewanek, R., Bhat, P., DiAntonio, A., & Collins, C. A.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-10-04
- Volume
- 191
- Issue
- 1
- Pages
- 211-223
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1968195620
- Cited by
- 275
- References
- 70
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Xiong, X., Wang, X., Ewanek, R., Bhat, P., DiAntonio, A., & Collins, C. A. (2010). Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. Journal of Cell Biology. https://doi.org/10.1083/jcb.201006039
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