The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Virtual nanoscopy: Generation of ultra-large high resolution electron microscopy maps
Open accessAbstract
A key obstacle in uncovering the orchestration between molecular and cellular events is the vastly different length scales on which they occur. We describe here a methodology for ultrastructurally mapping regions of cells and tissue as large as 1 mm2 at nanometer resolution. Our approach employs standard transmission electron microscopy, rapid automated data collection, and stitching to create large virtual slides. It greatly facilitates correlative light-electron microscopy studies to relate structure and function and provides a genuine representation of ultrastructural events. The method is scalable as illustrated by slides up to 281 gigapixels in size. Here, we applied virtual nanoscopy in a correlative light-electron microscopy study to address the role of the endothelial glycocalyx in protein leakage over the glomerular filtration barrier, in an immunogold labeling study of internalization of oncolytic reovirus in human dendritic cells, in a cryo-electron microscopy study of intact vitrified mouse embryonic cells, and in an ultrastructural mapping of a complete zebrafish embryo slice.
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Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499
Eskelinen, E.-L. (2008) · Autophagy · doi:10.4161/auto.5179 · Cited by 197
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Self-citationCorrelated light and electron microscopy: ultrastructure lights up!
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Metadata
- Authors
- Faas, F. G. A., Avramut, M. C., M. van den Berg, B., Mommaas, A. M., Koster, A. J., & Ravelli, R. B. G.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-08-06
- Volume
- 198
- Issue
- 3
- Pages
- 457-469
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2096256459
- Cited by
- 169
- References
- 2
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Faas, F. G. A., Avramut, M. C., M. van den Berg, B., Mommaas, A. M., Koster, A. J., & Ravelli, R. B. G. (2012). Virtual nanoscopy: Generation of ultra-large high resolution electron microscopy maps. Journal of Cell Biology. https://doi.org/10.1083/jcb.201201140
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