The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mechanistic insights into the regulation of metabolic enzymes by acetylation
Open accessAbstract
The activity of metabolic enzymes is controlled by three principle levels: the amount of enzyme, the catalytic activity, and the accessibility of substrates. Reversible lysine acetylation is emerging as a major regulatory mechanism in metabolism that is involved in all three levels of controlling metabolic enzymes and is altered frequently in human diseases. Acetylation rivals other common posttranslational modifications in cell regulation not only in the number of substrates it modifies, but also the variety of regulatory mechanisms it facilitates.
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Citations
Cites
Autophagy fights disease through cellular self-digestion
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Lysine acetylation targets protein complexes and co-regulates major cellular functions
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ATP-citrate lyase links cellular metabolism to histone acetylation
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Regulation of cellular metabolism by protein lysine acetylation
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Self-citationSIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
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Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
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Cited by
The growing landscape of lysine acetylation links metabolism and cell signalling
Choudhary, C., Weinert, B. T., Nishida, Y., Verdin, E., & Mann, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3841 · Cited by 1,324
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5
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“Lysine acetylation levels are coupled to metabolism and play key roles in regulating mitochondrial enzymes, chromatin biology, and other cellular processes (Chalkiadaki andGuarente, 2012; Verdin et al., 2010; Xiong and Guan, 2012).”
BackgroundPost-translational modifications in proteins: resources, tools and prediction methods
Ramazi, S., & Zahiri, J. (2021) · Database · doi:10.1093/database/baab012 · Cited by 772
Mitochondria as signaling organelles
Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576
Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation
Schneider, J. L., Suh, Y., & Cuervo, A. M. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.009 · Cited by 340
Metadata
- Authors
- Xiong, Y., & Guan, K.-L.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-07-23
- Volume
- 198
- Issue
- 2
- Pages
- 155-164
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2020016897
- Cited by
- 242
- References
- 16
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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