The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
Open accessAbstract
Cilia formation is a multi-step process that starts with the docking of a vesicle at the distal part of the mother centriole. This step marks the conversion of the mother centriole into the basal body, from which axonemal microtubules extend to form the ciliary compartment. How vesicles are stably attached to the mother centriole to initiate ciliary membrane biogenesis is unknown. Here, we investigate the molecular role of the mother centriolar component Cep164 in ciliogenesis. We show that Cep164 was indispensable for the docking of vesicles at the mother centriole. Using biochemical and functional assays, we identified the components of the vesicular transport machinery, the GEF Rabin8 and the GTPase Rab8, as interacting partners of Cep164. We propose that Cep164 is targeted to the apical domain of the mother centriole to provide the molecular link between the mother centriole and the membrane biogenesis machinery that initiates cilia formation.
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Metadata
- Authors
- Schmidt, K. N., Kuhns, S., Neuner, A., Hub, B., Zentgraf, H., & Pereira, G.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-12-17
- Volume
- 199
- Issue
- 7
- Pages
- 1083-1101
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1990436838
- Cited by
- 289
- References
- 68
- FWCI
- 10.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schmidt, K. N., Kuhns, S., Neuner, A., Hub, B., Zentgraf, H., & Pereira, G. (2012). Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis. Journal of Cell Biology. https://doi.org/10.1083/jcb.201202126
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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