Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

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Items 101–186 of 186

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19. Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
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20. Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration
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22. Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability
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27. Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling
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28. FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
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29. The impact of transcription-mediated replication stress on genome instability and human disease
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30. NHP2 downregulation counteracts hTR‐mediated activation of the DNA damage response at ALT telomeres
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31. Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins
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32. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress
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33. The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction
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34. SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells
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35. Single-Cell Tracking of A549 Lung Cancer Cells Exposed to a Marine Toxin Reveals Correlations in Pedigree Tree Profiles
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36. Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress
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37. Regulation of Structure-Specific Endonucleases in Replication Stress
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38. Cyclin A–CDK1 suppresses the expression of the CDK1 activator CDC25A to safeguard timely mitotic entry
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41. Oncogenic RAS in Cancers from the DNA Replication Stress and Senescence Perspective
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43. Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication
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45. TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
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47. Replication Stress in Cancer: Mechanistic Insights and Therapeutic Opportunities for Radiosensitization
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48. Genomic Instability of Pluripotent Stem Cells: Origin and Consequences
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49. Replication forks reverse at high frequency upon replication stress in Physarum polycephalum
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50. FBH1 and the replication stress response: Implications for genome stability and cancer development
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52. The fork protection complex generates DNA topological stress–induced DNA damage while ensuring full and faithful genome duplication
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55. Exploiting WEE1 Kinase Activity as FUS::DDIT3-Dependent Therapeutic Vulnerability in Myxoid Liposarcoma
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57. EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection
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60. Transcription-Replication Conflicts and Incomplete Replication as a Cause of Micronuclei-Driven Chromoanagenesis
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61. Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC
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64. 53BP1 nuclear body-marked replication stress in a human mammary cell model of BRCA2 deficiency
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65. Identificação de alvos moleculares associados à resistência e a sensibilidade aos antitumorais carboplatina e análogos de rebecamicina utilizando Saccharomyces cerevisiae como modelo celular
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66. Oncogenes induce a reversal of replication’s fortunes
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67. Signaling of DNA Replication Stress Through the ATR Checkpoint
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68. Replication stress induced by CCNE1 overexpression creates a dependency on XRCC2 at the replication fork
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69. Oncofetal HMGA2 as a key regulator of telomere stability through control of DNA topology
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73. Faculty Opinions recommendation of Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase.
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76. TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
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77. Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage
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78. Impact de l'haploinsuffisance d'ATR/CHK1 et de la Topoisomérase 1 sur la réplication et les Sites Fragiles Communs.
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79. The role of the histone chaperone ASF1 in recycling parental histones during DNA replication
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80. Etude de l'effondrement rapide des fourches de réplication lors d'un stress réplicatif
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81. Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal
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