Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

The Molecular Motor Toolbox for Intracellular Transport

Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

Chen, H., & Chan, D. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp326 · Cited by 1,506

The axonal transport of mitochondria

Saxton, W. M., & Hollenbeck, P. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.053850 · Cited by 1,218

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

Frezza, C., Cipolat, S., & Scorrano, L. (2007) · Nature Protocols · doi:10.1038/nprot.2006.478 · Cited by 1,188

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

Hirokawa, N., Niwa, S., & Tanaka, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.039 · Cited by 1,138

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

Sheng, Z., & Cai, Q. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3156 · Cited by 940

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

Wang, X., & Schwarz, T. L. (2009) · Cell · doi:10.1016/j.cell.2008.11.046 · Cited by 871

Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions

Verstreken, P., Ly, C. V., Venken, K. J. T., Koh, T.-W., Zhou, Y., & Bellen, H. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.018 · Cited by 841

The axonal transport of mitochondria

Hollenbeck, P. J., & Saxton, W. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02745 · Cited by 771

Kinesin-1 and Dynein Are the Primary Motors for Fast Transport of Mitochondria in Drosophila Motor Axons

Pilling, A. D., Horiuchi, D., Lively, C. M., & Saxton, W. M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0526 · Cited by 696

CYFIP1 governs the development of cortical axons by modulating calcium availability

Ricci, C., Midroit, M. J., Caicci, F., Achsel, T., Domínguez-Iturza, N., & Bagni, C. (2025) · Nature Communications · doi:10.1038/s41467-025-65801-0 · Cited by 1

Remodeling mitochondrial transport and cellular energetics in axonal regeneration and spinal cord injury

Huang, N., & Sheng, Z. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822427-4.00017-4 · Cited by 1

Integrated proteome, phospho-proteome and malonyl-proteome revealed a molecular alteration of breast cancer

Guo, C., Zhang, M., Jin, X., Zhu, C., Xu, R., Sun, J., & Qian, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-11573-y · Cited by 1

Buyang Huanwu decoction promotes neurological recovery after ischemic stroke by activating the Akt/PAK5/SNPH axis to enhance mitochondrial recruitment and axonal remodeling

Li, C., Zhang, Z., Cheng, J., Deng, Y., Zhang, X., Zhang, Z., Shang, H., & Hu, Y. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121860 · Cited by 1

Kif5b Modulates Processing and Secretion of von Willebrand Factor in Endothelial Cells and Mice

Luo, Y.-S., Yue, Z., Zhang, K., Liu, X., Hofer, E., & Huang, J. (2018) · Cardiovascular Pharmacology Open Access · doi:10.4172/2329-6607.1000249 · Cited by 1

Calcium Dysregulation and Mitochondrial Dysfunction Form A Vicious Cycle in Parkinson’s Disease

Hees, J. T. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.05.000920 · Cited by 1

BIOQUÍMICA MITOCONDRIAL E ESTRESSE OXIDATIVO NO TRANSTORNO BIPOLAR: NOVOS HORIZONTES

Cyrino, L. A. R., de Lima, D. D., Ullmann, O. M., Maia, T. P., & Sardo, A. C. (2020) · Revista Contexto & Saúde · doi:10.21527/2176-7114.2020.39.6-18 · Cited by 1

Microtubule Motor Proteins and the Mechanisms of Synaptic Plasticity

Васильева, Н. А., & Pivovarov, A. S. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0439-6 · Cited by 1

Author response: Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3

Auer, T. O., Xiao, T., Bercier, V., Gebhardt, C., Duroure, K., Concordet, J., Wyart, C., Suster, M. L., Kawakami, K., Wittbrodt, J., et al. (2015) · eLife · doi:10.7554/elife.05061.030 · Cited by 1

Axonal transport of Hrs is activity-dependent and rate limiting for synaptic vesicle protein degradationPreprint

Birdsall, V., Zhu, M. J., Kirwan, K., Imoto, Y., Watanabe, S., & Waites, C. L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.16.044818 · Cited by 1

Neuronal activity promotes axonal node-like clustering prior to myelination and remyelination in the central nervous systemPreprint

Ronzano, R., Perrot, C., Mazuir, E., Thétiot, M., Aigrot, M., Stheneur, P., Lejeune, F., Stankoff, B., Lubetzki, C., Sol‐Foulon, N., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.16.585168 · Cited by 1

Neuronal Mitochondrial Transport

Knight, A. L., Chen, Y., Sun, T., & Sheng, Z. (2015) · Wiley eBooks · doi:10.1002/9781119017127.ch7

Syntaphilin puts the brakes on axonal mitochondria

Short, B. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.2022if

Influência do cálcio e das proteínas Miro na mobilidade mitocondrial anteriormente e durante a agregação de proteínas envolvidas em neurodegeneração

Chaves, R. D. S. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2016.tde-05012016-154631

A survey of axonal transport function and motor behaviour in Drosophila models of amyotrophic lateral sclerosis

Baldwin, K. R. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Functions and Kinetics of Mitochondrial Fusion and Fission in the Axon: a Quantitative Study

Yu, Y. (2015) · KiltHub Repository · doi:10.1184/r1/6717419

ROS regulation of axonal mitochondrial transport

Liao, P. (2016) · Purdue e-Pubs (Purdue University System)

Estudo dos efeitos da superexpressão da alfa-sinucleína sobre o tráfego mitocondrial e autofagia em leveduras, células SH-SY5Y e neurônios dopaminérgicos derivados de hiPSC de pacientes com doença de Parkinson

Melo, T. Q. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2017.tde-01032017-131637

Natural and Synthetic GHSR1a Agonists as Neuroprotective Agents in Models of Parkinson's disease

Rees, D. J. (2017) · Cronfa (Swansea University) · doi:10.23889/suthesis.40946

Modulation of neuronal mitochondrial dynamics, autophagy and huntingtin proteostasis by HDAC inhibitors: Insights for Huntington's disease

Dias, P. G. G. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/3xwd-bf33

Regeneration of Retinal Ganglion Cell Axons

Park, K. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.23903-5

Vesicle Navigation of Microtubule Ends Distinguished by A Single Rate-Constant ModelPreprint

Gramlich, M. W., Balseiro-Gómez, S., Tabei, S. M. A., Parkes, M., & Yogev, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.21.214023

Mechanisms Regulating Movement and Distribution of Neuronal Mitochondria

Basu, H. (2020) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Regulation of intracellular traffic by TBK1 and its relevance to ALS

Villarroel‐Campos, D. (2020) · UCL Discovery (University College London)

Mechanisms of Dynamic Recruitment of the ESCRT Pathway in Axons

Birdsall, V. (2020) · doi:10.7916/d8-6ef2-j580

Mitochondrial response to axonal injury

Kedra, J. (2020) · TUScholarShare (Temple University)

Functions and dynamics of axonal mitochondria in development

Gallo, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817986-4.00006-7

Armcx1 Alleviates Secondary Brain Injury After Traumatic Brain Injury by Reducing Apoptosis and Axonal Injury in a Mouse Model of Controlled Cortical ImpactPreprint

Lu, D., Wang, Y., Liu, G., Wang, S., Wang, J., Sun, X., & Wu, Y. H. (2021) · Research Square · doi:10.21203/rs.3.rs-1100916/v1

Faculty Opinions recommendation of Synaptic activity controls autophagic vacuole motility and function in dendrites.

Sheng, Z., & Cheng, X. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.739839217.793584791

Regulation of Synaptic Transmission through Mitochondrial Positioning and Metabolism

Li, S., & Sheng, Z. (2024) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190932183.013.13 · Cited by 1

The Application of Framework Nucleic Acid‐Based Nanomaterials in the Treatment of Mitochondrial Dysfunction

Yao, L., & Zhang, T. (2024) · Wiley eBooks · doi:10.1002/9783527841912.ch4

Neuronal activity inhibits axonal mitochondrial transport in a region-specific mannerPreprint

Venneman, T., & Berghe, P. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.04.597338

Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device

Otomo, A., Nishijima, K., Murakami, Y., Ishikawa, M., Yudahira, H., Shimakura, K., Okano, H., Aoki, M., Kimura, H., & Hadano, S. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1590732

Caractérisation d'allèles de mitofusine associés à la maladie de Charcot-Marie-Tooth : mise en évidence de l'implication d'un déséquilibre entre fusion et fission mitochondriale dans le dysfonctionnement des neurones

Fissi, N. E. (2017) · theses.fr (ABES) · doi:10.70675/c83cba05z877bz4314z9573zbdf64fa8a1cc

Dynactin1 mutations associated with amyotrophic lateral sclerosis and their effect on axonal transport and neuromuscular junction formation

Bercier, V. (2017) · theses.fr (ABES) · doi:10.70675/97958154z085az46f7z984fz7595cc2bf079

Régulation du transport axonal par l'activité neuronale : Implication pour le développement des réseaux neuronaux

Moutaux, E. (2020) · theses.fr (ABES) · doi:10.70675/92768e39z0bb6z48a1z8b4az431471100ad3

Regulation of neuronal microtubule-based transport by polyglutamylation

Bodakuntla, S. (2019) · theses.fr (ABES) · doi:10.70675/25a5f130z3b63z4663zb3aez400da5d97e80

Systematic characterization of a large number of Microtubule-Associated Proteins using purification-free TIRF-reconstitution assays

Jijumon, A. S. (2021) · theses.fr (ABES) · doi:10.70675/a91e897dze839z49aezbde4z6f7bfa86d70b

Développement d’une méthode de mesure et d’analyse du transport intraneuronal dans le cerveau de larve de poissons-zèbre par suivi de nanocristaux non-linéaires en microscopie de second-harmonique : application à l’étude d’anomalies de transport chez des poissons portant une mutation retrouvée dans des neuropathies humaines.

Terras, F. (2020) · doi:10.70675/872df6d1ze1b9z4a8dzb02dzad4656ff10f0

Bases métaboliques du développement neuronal : rôles de la kinase NUAK1 dans la régulation des mitochondries axonales

Lanfranchi, M. (2021) · theses.fr (ABES) · doi:10.70675/247335b1zba7fz4005zafbdzdc43c088d75f

Modèles cellulaires pour l'étude des mécanismes sous jacents aux maladies neuromusculaires rares

Puma, A. R. (2023) · theses.fr (ABES) · doi:10.70675/b50d3134z80fbz4d0dz8b6ez61a950ee0307

Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis

Yang, L., Björklund, M., Yi, C., Chen, S., & Hong, Z. (2026) · The Journal of Cell Biology · doi:10.1083/jcb.202506032

Mitochondrial morphology and function are tuned by microtubule associationPreprint

Fatima, N., Redpath, G., Jahan, Z., Nassar, O., Ariotti, N., & Ananthanarayanan, V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.13.731791

Syntaphilin Regulates Epithelial-Mesenchymal Transition and Metastasis in Gastric Cancer via the FAK/NF-κB/MMP-9 Signaling Pathway

Choi, H. J., & Park, J.-M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156564

Septic Cardiomyopathy and Mitochondrial Quality Control

Pu, X., Yan, Z., Liu, Z., Chang, X., & Liu, R. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl47390

Mitochondrial molecular diversity in the brain

Sainz, A. G., & Wang, X. (2026) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2026.103270

Microtubule posttranslational modifications provide unique recognition patterns for associated proteins

Krishnan, A., Desvigne-Hansch, E., Henriot, V., Dodoková, A., Khanfir, S., Genova, M., Grycová, L., Magiera, M. M., Braun, M., Lánský, Z., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00908-8 · Cited by 1

Mapping Mitochondrial Architecture in the Brain: Methods and Insights

Miller, E. K., & Nahirney, P. C. (2026) · Neuromethods · doi:10.1007/978-1-0716-5456-9_5

Molecular Mechanisms of Mitochondrial Transport in Neurons

Babić, M. (2015) · UA Campus Repository (The University of Arizona)

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

Kang, J.-S., Tian, J.-H., Pan, P.-Y., Zald, P., Li, C., Deng, C., & Sheng, Z.-H. (2008) · Cell · doi:10.1016/j.cell.2007.11.024 · Cited by 598

SUMMARY

Kang, J.-S., Tian, J.-H., Pan, P.-Y., Zald, P. B., Li, C., & Sheng, Z.-H. (2015)

Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring

Park, C., Lee, S., Hong, J., Suh, Y., Park, S. J., Suh, B. K., Woo, Y., Choi, J., Huh, J., Kim, Y., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0250-2 · Cited by 33

Dynein Light Chain LC8 Regulates Syntaphilin-Mediated Mitochondrial Docking in Axons

Chen, Y., Gerwin, C. M., & Sheng, Z. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1472-09.2009 · Cited by 88

Neuronal activity inhibits mitochondrial transport only in synaptically connected segments of the axon

Venneman, T., & Berghe, P. V. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1509283 · Cited by 2