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A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells
Open accessAbstract
How adherent and contractile systems coordinate to promote cell shape changes is unclear. Here, we define a counterbalanced adhesion/contraction model for cell shape control. Live-cell microscopy data showed a crucial role for a contractile meshwork at the top of the cell, which is composed of actin arcs and myosin IIA filaments. The contractile actin meshwork is organized like muscle sarcomeres, with repeating myosin II filaments separated by the actin bundling protein α-actinin, and is mechanically coupled to noncontractile dorsal actin fibers that run from top to bottom in the cell. When the meshwork contracts, it pulls the dorsal fibers away from the substrate. This pulling force is counterbalanced by the dorsal fibers’ attachment to focal adhesions, causing the fibers to bend downward and flattening the cell. This model is likely to be relevant for understanding how cells configure themselves to complex surfaces, protrude into tight spaces, and generate three-dimensional forces on the growth substrate under both healthy and diseased conditions.
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Citations
Cited by
Fluorescence nanoscopy in cell biology
Sahl, S. J., Hell, S. W., & Jakobs, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.71 · Cited by 990
Cellular chirality arising from the self-organization of the actin cytoskeleton
Tee, Y. H., Shemesh, T., Thiagarajan, V., Hariadi, R. F., Anderson, K. L., Page, C., Volkmann, N., Hanein, D., Sivaramakrishnan, S., Kozlov, M. M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3137 · Cited by 416
Focal adhesions, stress fibers and mechanical tension
Burridge, K., & Guilluy, C. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.029 · Cited by 409
SIMcheck: a Toolbox for Successful Super-resolution Structured Illumination Microscopy
Ball, G., Demmerle, J., Kaufmann, R., Davis, I., Dobbie, I. M., & Schermelleh, L. (2015) · Scientific Reports · doi:10.1038/srep15915 · Cited by 294
Campellone, K. G., Lebek, N. M., & King, V. L. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151301 · Cited by 50
Metadata
- Authors
- Burnette, D. T., Shao, L., Ott, C., Pasapera, A. M., Fischer, R. S., Baird, M. A., Der Loughian, C., Delanoe-Ayari, H., Paszek, M. J., Davidson, M. W., Betzig, E., & Lippincott-Schwartz, J.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2014-04-07
- Volume
- 205
- Issue
- 1
- Pages
- 83-96
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1982149574
- Cited by
- 184
- References
- 0
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells. https://app.cochat.ai/papers/10.1083/jcb.201311104
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- Burnette, D. T., Shao, L., Ott, C., Pasapera, A. M., Fischer, R. S., Baird, M. A., Der Loughian, C., Delanoe-Ayari, H., Paszek, M. J., Davidson, M. W., Betzig, E., & Lippincott-Schwartz, J. (2014). A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells. Journal of Cell Biology. https://doi.org/10.1083/jcb.201311104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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