The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Targeting potassium channels in cancer
Open accessAbstract
Potassium channels are pore-forming transmembrane proteins that regulate a multitude of biological processes by controlling potassium flow across cell membranes. Aberrant potassium channel functions contribute to diseases such as epilepsy, cardiac arrhythmia, and neuromuscular symptoms collectively known as channelopathies. Increasing evidence suggests that cancer constitutes another category of channelopathies associated with dysregulated channel expression. Indeed, potassium channel–modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation–dependent and noncanonical ion permeation–independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.
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Cites
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Molecular subgroups of medulloblastoma: the current consensus
Taylor, M. D., Northcott, P. A., Korshunov, A., Remke, M., Cho, Y.-J., Clifford, S. C., Eberhart, C. G., Parsons, D. W., Rutkowski, S., Gajjar, A., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0922-z · Cited by 1,936
Membrane potential and cancer progression
Yang, M., & Brackenbury, W. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00185 · Cited by 614
Membrane Potential Controls Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells
Sundelacruz, S., Levin, M., & Kaplan, D. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003737 · Cited by 249
Induction of Mitosis in Mature Neurons in Central Nervous System by Sustained Depolarization
Cone, C. D., & Cone, C. M. (1976) · Science · doi:10.1126/science.56781 · Cited by 208
Membrane potential changes during mitogenic stimulation of mouse spleen lymphocytes
Kiefer, H., Blume, A. J., & Kaback, H. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.2200 · Cited by 158
Role of Kir4.1 channels in growth control of glia
Higashimori, H., & Sontheimer, H. (2007) · Glia · doi:10.1002/glia.20574 · Cited by 101
Cited by
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
Nagaraja, S., Vitanza, N. A., Woo, P. J., Taylor, K. R., Liu, F., Zhang, L., Li, M., Meng, W., Ponnuswami, A., Sun, W., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.03.011 · Cited by 396
Cancer as a channelopathy: ion channels and pumps in tumor development and progression
Litan, A., & Langhans, S. A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00086 · Cited by 276
Metadata
- Authors
- Huang, X., & Jan, L. Y.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2014-07-21
- Volume
- 206
- Issue
- 2
- Pages
- 151-162
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2100444908
- Cited by
- 330
- References
- 7
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
