The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion
Open accessAbstract
Ca2+ signaling has been increasingly implicated in cancer invasion and metastasis, and yet, the underlying mechanisms remained largely unknown. In this paper, we report that STIM1- and Orai1-mediated Ca2+ oscillations promote melanoma invasion by orchestrating invadopodium assembly and extracellular matrix (ECM) degradation. Ca2+ oscillation signals facilitate invadopodial precursor assembly by activating Src. Disruption of Ca2+ oscillations inhibited invadopodium assembly. Furthermore, STIM1 and Orai1 regulate the proteolysis activity of individual invadopodia. Mechanistically, Orai1 blockade inhibited the recycling of MT1–matrix metalloproteinase (MMP) to the plasma membrane and entrapped MT1-MMP in the endocytic compartment to inhibit ECM degradation. STIM1 knockdown significantly inhibited melanoma lung metastasis in a xenograft mouse model, implicating the importance of this pathway in metastatic dissemination. Our findings provide a novel mechanism for Ca2+-mediated cancer cell invasion and shed new light on the spatiotemporal organization of store-operated Ca2+ signals during melanoma invasion and metastasis.
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Citations
Cites
The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · cited 2×
“SOCE is critical for melanoma metastasis Gaining invasiveness is one of the first and most critical steps of metastasis (Fidler, 2003; Nürnberg et al., 2011).”
Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats
Hamed, M. A., Ali, S. A., & Saba El-Rigal, N. (2012) · The Scientific World Journal · doi:10.1100/2012/840421 · Cited by 130
Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion
Wollman, R., & Meyer, T. (2012) · Nature Cell Biology · doi:10.1038/ncb2614 · Cited by 119
Cited by
Store-Operated Calcium Channels
Prakriya, M., & Lewis, R. S. (2015) · Physiological Reviews · doi:10.1152/physrev.00020.2014 · Cited by 1,239
Marchi, S., Giorgi, C., Galluzzi, L., & Pinton, P. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.017 · Cited by 235
STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment
Frisch, J., Angenendt, A., Hoth, M., Prates Roma, L., & Lis, A. (2019) · Cancers · doi:10.3390/cancers11040457 · Cited by 68
Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma
Raymond, J. H., Aktary, Z., Larue, L., & Delmas, V. (2022) · Cancers · doi:10.3390/cancers14030706 · Cited by 20
Metadata
- Authors
- Sun, J., Lu, F., He, H., Shen, J., Messina, J., Mathew, R., Wang, D., Sarnaik, A. A., Chang, W.-C., Kim, M., Cheng, H., & Yang, S.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2014-11-17
- Volume
- 207
- Issue
- 4
- Pages
- 535-548
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2093672972
- Cited by
- 171
- References
- 3
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Sun, J., Lu, F., He, H., Shen, J., Messina, J., Mathew, R., Wang, D., Sarnaik, A. A., Chang, W.-C., Kim, M., Cheng, H., & Yang, S. (2014). STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion. Journal of Cell Biology. https://doi.org/10.1083/jcb.201407082
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