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Cited by 60Microtubule and mitosis dynamicsDevelopmental Biology and Gene RegulationCellular Mechanics and Interactions

The postmitotic midbody: Regulating polarity, stemness, and proliferation

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Peterman, Eric, Prekeris, Rytis·2019·Journal of Cell Biology
DOI 10.1083/jcb.201906148PMC PMC6891101
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Abstract

Abscission, the final stage of cell division, requires well-orchestrated changes in endocytic trafficking, microtubule severing, actin clearance, and the physical sealing of the daughter cell membranes. These processes are highly regulated, and any missteps in localized membrane and cytoskeleton dynamics often lead to a delay or a failure in cell division. The midbody, a microtubule-rich structure that forms during cytokinesis, is a key regulator of abscission and appears to function as a signaling platform coordinating cytoskeleton and endosomal dynamics during the terminal stages of cell division. It was long thought that immediately following abscission and the conclusion of cell division, the midbody is either released or rapidly degraded by one of the daughter cells. Recently, the midbody has gained prominence for exerting postmitotic functions. In this review, we detail the role of the midbody in orchestrating abscission, as well as discuss the relatively new field of postabscission midbody biology, particularly focusing on how it may act to regulate cell polarity and its potential to regulate cell tumorigenicity or stemness.

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  • Release of the spindle midbody during abscission was visualized.

    “Importantly, we could also directly visualize how one of the half-spindle remnants often repositions to the cytoplasmic bridge formed by the midzone MTs after anaphase (Piel et al., 2001) and the release of the spindle midbody during abscission (Peterman and Prekeris 2019).”

    From A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle (2023) · cites this paper as Peterman and Prekeris 2019

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Cited by

Sorted by citations

Authors
Peterman, E., & Prekeris, R.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Prekeris, Rytis
ORCID
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2019-11-05
Volume
218
Issue
12
Pages
3903-3911
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.201906148
PMC
PMC6891101
OpenAlex
W2987451180
Cited by
60
References
1
Citations by year
2026: 7 · 2025: 9 · 2024: 6 · 2023: 10 · 2022: 16 · 2021: 7 · 2020: 4
FWCI
0.79
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (DK064380, GM122768)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
midbody, abscission, cytokinesis, cell polarity, stemness, cell proliferation, microtubule severing, endosomal trafficking, membrane trafficking, cytoskeletal dynamics, tumorigenicity
MeSH terms
Actins, Animals, Cell Division, Cell Membrane, Cytoskeleton, Endocytosis, HeLa Cells, Humans, Microtubules, Mitosis, Spindle Apparatus, Neoplasms, Phagocytes, Endosomes, Stem Cells, Signal Transduction, Cell Polarity, Cell Line, Tumor, Cytokinesis, Cell Proliferation, Endosomal Sorting Complexes Required for Transport

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