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The Early Changes in the Axoplasm during Wallerian Degeneration
Open accessAbstract
Axoplasmic changes were studied in the saphenous nerve of the albino rat during the early stages of Wallerian degeneration. The axons were examined at 0, 24, and 48 hours after the surgical transection of the nerve. The material was fixed in 2 per cent OsO4 in phosphate buffer (pH 7.2–7.5) with sucrose (added to a final osmolar concentration of ∼0.37 M). The earliest changes were seen in the endoplasmic reticulum which became fragmented into rows of small vesicles. Then, between 24 and 48 hours, the neurofilaments underwent complete disintegration and the axoplasm became filled with finely granular material which later formed irregular clumps surrounded by a structureless matrix, probably fluid in vivo. The fragmentation of the neurofilaments was accompanied by pronounced swelling of the mitochondria.
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Citations
Cited by
LYSOSOMES IN THE RAT SCIATIC NERVE FOLLOWING CRUSH
Holtzman, E., & Novikoff, A. B. (1965) · The Journal of Cell Biology · doi:10.1083/jcb.27.3.651 · Cited by 323
The normal sural nerve in man: II. Changes in the axons and Schwann cells due to ageing
Ochoa, J., & Mair, W. G. P. (1969) · Acta Neuropathologica · doi:10.1007/bf00690643 · Cited by 292
Future Perspectives in Nerve Repair and Regeneration
Tos, P., Ronchi, G., Geuna, S., & Battiston, B. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-420045-6.00008-0 · Cited by 48
Metadata
- Authors
- Vial, J. D.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1958-09-25
- Volume
- 4
- Issue
- 5
- Pages
- 551-556
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2168138669
- Cited by
- 161
- References
- 0
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Vial, J. D. (1958). The Early Changes in the Axoplasm during Wallerian Degeneration. The Journal of Cell Biology. https://doi.org/10.1083/jcb.4.5.551
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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