Future Perspectives in Nerve Repair and Regeneration

Tos, Pierluigi; Ronchi, Giulia; Geuna, Stefano; Battiston, Bruno

doi:10.1016/b978-0-12-420045-6.00008-0

Cited by 48Nerve injury and regenerationNerve Injury and RehabilitationPeripheral Neuropathies and Disorders

Future Perspectives in Nerve Repair and Regeneration

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Tos, Pierluigi, Ronchi, Giulia, Geuna, Stefano, Battiston, Bruno·2013·International Review of Neurobiology

DOI 10.1016/b978-0-12-420045-6.00008-0

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Abstract

After peripheral nerve injuries, the process of nerve regeneration and target reinnervation is very complex and depends on many different events occurring not only at the lesion site but also proximally and distally to it. In spite of the recent scientific and technological advancements, the need to find out new strategies to improve clinical nerve repair and regeneration remains. To reach this goal, the therapeutic strategy should thus exert its effects at different levels in order to simultaneously potentiate axonal regeneration, increase neuronal survival, modulate central reorganization, and inhibit or reduce target organ atrophy. It is expected that this multilevel approach might lead to significant improvement in the functional outcome and thus the quality of life of the patients suffering from peripheral nerve injury.

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Due to environmental inhibitory factors in central nervous system, nerve axon regeneration ability is limited and often cannot get good therapeutic effect.
“Due to the existence of environmental inhibitory factors in the central nervous system, the ability of nerve axon regeneration is limited, and often cannot get a good therapeutic effect [176, 177].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [177]
Section 2, “Changes at the Nerve Level” (page unavailable), says myelin debris contains molecules inhibitory to axonal growth after peripheral nerve injury. The Introduction (page unavailable) also reports poor functional outcomes after peripheral nerve repair, but attributes them to target-organ atrophy. The paper does not establish that inhibitory factors in the central nervous system cause the limited regeneration and poor therapeutic outcomes claimed here. (LLM, conf=0.85)
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Confocal imaging of Schwann‐cell migration along muscle‐vein combined grafts used to bridge nerve defects in the rat
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Proteasome inhibition suppresses Schwann cell dedifferentiation in vitro and in vivo
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Comparison of fresh and predegenerated muscle‐vein‐combined guides for the repair of rat median nerve
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Lipid Metabolism During Early Stages of Wallerian Degeneration in the Rat Sciatic Nerve
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Improvement of Sciatic Nerve Regeneration Using Laminin-Binding Human NGF-β
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Nogo-C is sufficient to delay nerve regeneration
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C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury
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Manual stimulation of forearm muscles does not improve recovery of motor function after injury to a mixed peripheral nerve
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Adhesion molecule L1 overexpressed under the control of the neuronal Thy-1 promoter improves myelination after peripheral nerve injury in adult mice
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Obstetric Brachial Plexus Palsy: A Large Animal Model for Traction Injury and its Repair
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mRNA expression of fibroblast growth factors and hepatocyte growth factor in rat plantaris muscle following denervation and compensatory overload
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Lack of topographic specificity in nerve fiber regeneration of rat forelimb mixed nerves
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Comparative study of different surgical procedures using sensory nerves or neurons for delaying atrophy of denervated skeletal muscle
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Untitled work
(1997) · doi:10.1002/(sici)1097-0185(199707)248:3

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The sciatic nerve injury model in pre-clinical research
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Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
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Adipose-Derived Mesenchymal Stem Cells Applied in Fibrin Glue Stimulate Peripheral Nerve Regeneration
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Mesenchymal Stem Cell‐Derived Mitochondria Enhance Extracellular Matrix‐Derived Grafts for the Repair of Nerve Defect
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Carnosine improves functional recovery and structural regeneration after sciatic nerve crush injury in rats
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Therapeutic Effect of Vinorine on Sciatic Nerve Injured Rat
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PVDF piezoelectric neural conduit incorporated pre-differentiated adipose-derived stem cells may accelerate the repair of peripheral nerve injury
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Electrical stimulation attenuates morphological alterations and prevents atrophy of the denervated cranial tibial muscle
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Transcriptional landscape of alternative splicing during peripheral nerve injury
Zhao, L., & Yi, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27446 · Cited by 18 · see citing works
Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury
Li, Y., Sun, Y., Cai, M., Zhang, H., Gao, N., Huang, H., Cui, S., & Yao, D. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00210 · Cited by 16 · see citing works
Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and Neuropathic Pain Induced by Sciatic Nerve Injury Through Inactivating NF-κB and JNK
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Strategies to improve nerve regeneration after radical prostatectomy: a narrative review
Geuna, S., Muratori, L., Fregnan, F., Manfredi, M., Bertolo, R. G., & Porpiglia, F. (2018) · Minerva Urologica e Nefrologica · doi:10.23736/s0393-2249.18.03157-0 · Cited by 15 · see citing works
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Dysfunctions of the stomatognathic system and vocal aspects in Fahr disease: case report
dos Santos, K. W., de Fraga, B. F., & Cardoso, M. C. D. A. F. (2014) · CoDAS · doi:10.1590/2317-1782/2014498in · Cited by 14 · see citing works
Effects of Treatment of Treadmill Combined with Electro-Acupuncture on Tibia Bone Mass and Substance PExpression of Rabbits with Sciatic Nerve Injury
Wang, Y., Tang, Q., Zhu, L., Huang, R., Huang, L., Koleini, M., & Zou, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164652 · Cited by 14 · see citing works
Characterization of Glial Cell Models andIn VitroManipulation of the Neuregulin1/ErbB System
Pascal, D., Giovannelli, A., Gnavi, S., Hoyng, S. A., de Winter, F., Morano, M., Fregnan, F., Dell’Albani, P., Zaccheo, D., Perroteau, I., et al. (2014) · BioMed Research International · doi:10.1155/2014/310215 · Cited by 13 · see citing works
Reduced inflammatory factor expression facilitates recovery after sciatic nerve injury in TLR4 mutant mice
Tang, G., Yao, J., Shen, R., Aiyu, J., Ma, K., Cong, B., Wang, F., Zhu, L., Wang, X., Ding, Y., et al. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.12.007 · Cited by 12 · see citing works
Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats
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Application of PLCL as a biodegradable polymer in biomedical engineering
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“Due to the existence of environmental inhibitory factors in the central nervous system, the ability of nerve axon regeneration is limited, and often cannot get a good therapeutic effect [176, 177].”
Cortical Plasticity After Peripheral Nerve Injury
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Timing and Decision-Making in Peripheral Nerve Trauma
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Authors: Tos, P., Ronchi, G., Geuna, S., & Battiston, B.
Affiliations: CTO Hospital (IT)
Neuroscience Institute Cavalieri Ottolenghi (IT)
Corresponding author: Geuna, Stefano
ORCID: Tos, Pierluigi
Ronchi, Giulia
Geuna, Stefano
Battiston, Bruno
Venue: International Review of Neurobiology
Publisher: Elsevier
Published: 2013
Volume: 109
Pages: 165-192
ISSN: 0074-7742 (ISSN-L)
DOI: 10.1016/b978-0-12-420045-6.00008-0
OpenAlex: W2403101800
Cited by: 48
References: 152
Citations by year: 2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 9 · 2016: 3 · 2015: 4 · 2014: 7
FWCI: 7.68
Type: book chapter
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: International review of neurobiology (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
Funders: Compagnia di San Paolo (278612, FP7-HEALTH-2011)
Ministero dell’Istruzione, dell’Università e della Ricerca
FP7 Health (278612)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords: peripheral nerve injury, nerve regeneration, nerve repair, axon regeneration, neuronal survival, central nervous system reorganization, functional recovery
MeSH terms: Animals, Brain, Humans, Nerve Regeneration, Neuronal Plasticity, Neurosurgical Procedures, Recovery of Function, Tissue Engineering, Peripheral Nerve Injuries

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