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Effects of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils.
Open accessAbstract
In human peripheral blood polymorphonuclear leukocytes and lymphocytes, GSH-oxidizing agents promote the movement of surface-bound concanavalin A (Con A) into caps and inhibit the assembly of microtubules (MT) that is normally induced by Con A binding. Con A capping and inhibition of MT assembly occur when GSH levels in cell suspensions are decreased by 30-70%, and return to GSH to control levels is accompanied by the appearance of cytoplasmic MT and by inhibition of the capping response with Con A. Oxidation of GSH markedly stimulates the hexose monophosphate shunt, and regeneration of GSH occurs rapidly. The data indicate that MT cannot be assembled or maintained in the face of decreased GSH levels. Thus, GSH homeostasis becomes critical during physiological events such as phagocytosis which simultaneously induce the assembly of MT and the production of agents like H2O2 that can oxidize GSH.
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Cited by
Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.
Toledano, M. B., & Leonard, W. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4328 · Cited by 657
Oxidative stress and antioxidants: exposure and impact on female fertility
Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn011 · Cited by 351
[11] Diamide: An oxidant probe for thiols
Kosower, N. S., & Kosower, E. M. (1995) · Methods in Enzymology · doi:10.1016/0076-6879(95)51116-4 · Cited by 340
ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation
Stojkov, D., Amini, P., Oberson, K., Sokollik, C., Duppenthaler, A., Simon, H.-U., & Yousefi, S. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201611168 · Cited by 142
Metadata
- Authors
- Oliver, J. M., Albertini, D. F., & Berlin, R. D.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1976-12-01
- Volume
- 71
- Issue
- 3
- Pages
- 921-932
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2006058262
- Cited by
- 219
- References
- 0
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Effects of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils. https://app.cochat.ai/papers/10.1083/jcb.71.3.921
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- Oliver, J. M., Albertini, D. F., & Berlin, R. D. (1976). Effects of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils. The Journal of cell biology. https://doi.org/10.1083/jcb.71.3.921
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