Specification of cell morphology by endogenous determinants.
Open accessAbstract
We are studying the mechanisms by which cells elaborate their differentiated morphologies. Here we discuss one aspect of this issue: the specification of the detailed shape of individual cells. We describe an experimental system in which endogenous determinants of morphology are expressed. These determinants originally were detected in the morphological relationships between sister neuroblastoma cells. Approaches to analyzing these relationships are presented. The properties and behavior of the endogenous determinants have been partially characterized by further experiments, which are also described. The significance and the prospects for further analysis of our findings are discussed.
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Various components of the neuronal cytoskeleton are crucial for the differentiation, elaboration, and maintenance of axons and dendrites.
“Several lines of evidence indicate that the various components of the neuronal cytoskeleton are crucial for the differentiation, elaboration, and maintenance of axons and dendrites (for reviews, see Lasek et al., 1983;Solomon, 1981;Solomon and Zurn, 198 1).”
From Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture (1986) · cites this paper as Solomon, 1981
The opening discussion (p. 547) reports that disrupting microtubules or microfilaments inhibits extension of axonlike neurites in cultured cells of neuronal origin, and says three cytoskeletal components may participate in the assumption and loss of asymmetric shape. This supports a role in neurite elaboration and retention, but the paper's qualified discussion does not establish that these components are crucial for the differentiation, elaboration, and maintenance of both axons and dendrites generally. (LLM, conf=0.85)
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Caceres, A., Banker, G., & Binder, L. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00714.1986 · Cited by 367 · see citing works
- Authors
- Solomon, F.
- Corresponding author
- Solomon, F
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1981-09-01
- Volume
- 90
- Issue
- 3
- Pages
- 547-553
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2111906
- OpenAlex
- W2118742421
- Cited by
- 74
- References
- 0
- Citations by year
- 2020: 1 · 2016: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- cell morphology, neuroblastoma cells, sister cells, cell-cell interactions, cell differentiation, morphological relationships
- MeSH terms
- Axons, Cell Membrane, Cell Movement, Cells, Cultured, Cytoskeleton, Microtubules, Mitosis, Neuroblastoma, Neurons, Surface Properties
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