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Polarity orientation of axonal microtubules.
Open accessAbstract
The polarity orientation of cellular microtubules is widely regarded to be important in understanding the control of microtubule assembly and microtubule-based motility in vivo. We have used a modification of the method of Heidemann and McIntosh (Nature (Lond.). 286:517-519) to determine the polarity orientation of axonal microtubules in postganglionic sympathetic fibers of the cat. In fibers from three cats we were able to visualize the polarity of 68% of the axonal microtubules; of these, 96% showed the same polarity orientation. Our interpretation is that the rapidly growing end of all axonal microtubules is distal to the cell body. We support Kirschner's hypothesis on microtubule organizing centers. (J. Cell Biol. 86:330-334), although this interpretation raises questions about the continuity of axonal microtubules. Our results are inconsistent with a number of models for axonal transport based on force production on the surface of microtubules in which the direction of force is determined by the polarity of microtubules.
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Citations
Cited by
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Janke, C., & Magiera, M. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0214-3 · Cited by 956
Baas, P. W., Deitch, J. S., Black, M. M., & Banker, G. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8335 · Cited by 742
Pleasure, S., Page, C., & Lee, V. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01802.1992 · Cited by 608
Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons
Chen, J., Kanai, Y., Cowan, N. J., & Hirokawa, N. (1992) · Nature · doi:10.1038/360674a0 · Cited by 601
Kozminski, K. G., Beech, P. L., & Rosenbaum, J. L. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.6.1517 · Cited by 586
Metadata
- Authors
- Heidemann, S. R., Landers, J. M., & Hamborg, M. A.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1981-02-22
- Volume
- 91
- Issue
- 3
- Pages
- 661-665
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2170671667
- Cited by
- 343
- References
- 0
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Polarity orientation of axonal microtubules. https://app.cochat.ai/papers/10.1083/jcb.91.3.661
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- Heidemann, S. R., Landers, J. M., & Hamborg, M. A. (1981). Polarity orientation of axonal microtubules. The Journal of cell biology. https://doi.org/10.1083/jcb.91.3.661
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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