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Fibronectins: multifunctional modular glycoproteins.
Open accessAbstract
Fibronectins are large glycoproteins that have been implicated in a wide variety of cellular properties, particularly those involving the interactions of cells with extracellular materials. These properties include cell adhesion, morphology, cytoskeletal organization, migration, differentiation, oncogenic transformation, phagocytosis, and hemostasis. During the past several years, investigations in many laboratories have analyzed the expression, functions, and structure of fibronectins. These studies have revealed that fibronectins have a complex molecular structure consisting of multiple specific binding sites, and the complex biological phenomena in which fibronectins participate can now be considered in terms of this structure. In this brief article we will review the current understanding of the structure and properties of fibronectins. Because a number of comprehensive reviews on various aspects of fibronectins have been published (1-13), we shall focus on overall concepts, recent developments and promising future research directions in this rapidly expanding field.
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Cited by
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Targeting integrin pathways: mechanisms and advances in therapy
Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275
Chiquet-Ehrismann, R., Mackie, E. J., Pearson, C. A., & Sakakura, T. (1986) · Cell · doi:10.1016/0092-8674(86)90374-0 · Cited by 992
Molecular Biology of Fibronectin
Hynes, R. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000435 · Cited by 601
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Metadata
- Authors
- Hynes, R. O., & Yamada, K. M.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1982-11-01
- Volume
- 95
- Issue
- 2
- Pages
- 369-377
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2024051243
- Cited by
- 1,326
- References
- 0
- FWCI
- 69.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hynes, R. O., & Yamada, K. M. (1982). Fibronectins: multifunctional modular glycoproteins. The Journal of cell biology. https://doi.org/10.1083/jcb.95.2.369
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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