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THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
Open accessAbstract
It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.
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Cited by
Gheblawi, M., Wang, K., Viveiros, A., Nguyen, Q., Zhong, J.-C., Turner, A. J., Raizada, M. K., Grant, M. B., & Oudit, G. Y. (2020) · Circulation Research · doi:10.1161/circresaha.120.317015 · Cited by 1,882
Nakamura, Y., Yamamoto, N., Sakai, K., & Takano, T. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76745-5 · Cited by 555
Li, X. C., Zhang, J., & Zhuo, J. L. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.06.005 · Cited by 435
A continuous spectrophotometric assay for angiotensin converting enzyme
Holmquist, B., Bünning, P., & Riordan, J. F. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90769-3 · Cited by 406
Guerrero, L., Castillo, J., Quiñones, M., Garcia-Vallvé, S., Arola, L., Pujadas, G., & Muguerza, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049493 · Cited by 391
Metadata
- Authors
- Skeggs, L. T., Kahn, J. R., & Shumway, N. P.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1956-03-01
- Volume
- 103
- Issue
- 3
- Pages
- 295-299
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2101610495
- Cited by
- 1,032
- References
- 0
- FWCI
- 16.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Skeggs, L. T., Kahn, J. R., & Shumway, N. P. (1956). THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.103.3.295
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
