Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2
Open accessAbstract
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-CoV-2 receptor. ACE2 is widely expressed, including, in the lungs, cardiovascular system, gut, kidneys, central nervous system, and adipose tissue. ACE2 has recently been identified as the SARS-CoV-2 receptor, the infective agent responsible for coronavirus disease 2019, providing a critical link between immunity, inflammation, ACE2, and cardiovascular disease. Although sharing a close evolutionary relationship with SARS-CoV, the receptor-binding domain of SARS-CoV-2 differs in several key amino acid residues, allowing for stronger binding affinity with the human ACE2 receptor, which may account for the greater pathogenicity of SARS-CoV-2. The loss of ACE2 function following binding by SARS-CoV-2 is driven by endocytosis and activation of proteolytic cleavage and processing. The ACE2 system is a critical protective pathway against heart failure with reduced and preserved ejection fraction including, myocardial infarction and hypertension, and against lung disease and diabetes mellitus. The control of gut dysbiosis and vascular permeability by ACE2 has emerged as an essential mechanism of pulmonary hypertension and diabetic cardiovascular complications. Recombinant ACE2, gene-delivery of Ace2 , Ang 1–7 analogs, and Mas receptor agonists enhance ACE2 action and serve as potential therapies for disease conditions associated with an activated renin-angiotensin system. rhACE2 (recombinant human ACE2) has completed clinical trials and efficiently lowered or increased plasma angiotensin II and angiotensin 1-7 levels, respectively. Our review summarizes the progress over the past 20 years, highlighting the critical role of ACE2 as the novel SARS-CoV-2 receptor and as the negative regulator of the renin-angiotensin system, together with implications for the coronavirus disease 2019 pandemic and associated cardiovascular diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ACE2 serves as a SARS-CoV-2 entry route in human cells, but as this enzyme is internalized following virus binding, its enzyme function is lost.
“ACE2, independent from its enzymatic activity, serves as SARS-CoV-2 entry route in human cells, but as this enzyme is internalized following virus binding, its enzyme function is lost [6, 116].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [116]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969 · see citing works
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415 · see citing works
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148 · see citing works
La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463 · see citing works
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897 · see citing works
Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Walls, A. C., Park, Y.-J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020) · doi:10.1101/2020.02.19.956581 · Cited by 8,586 · see citing works
Chan, J., Yuan, S.-F., Kok, K.-H., To, K., Chu, H., Yang, J., Xing, F., Liu, J.-L., Yip, C., Poon, R., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30154-9 · Cited by 8,450 · see citing works
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493 · see citing works
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923 · see citing works
Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., & van Goor, H. (2004) · The Journal of Pathology · doi:10.1002/path.1570 · Cited by 5,676 · see citing works
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
Yan, R., Zhang, Y., Li, Y., Xia, L., Guo, Y., & Zhou, Q. (2020) · Science · doi:10.1126/science.abb2762 · Cited by 4,950 · see citing works
Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China
Shi, S., Qin, M., Shen, B., Cai, Y., Liu, T., Yang, F., Gong, W., Liu, X., Liang, J., Zhao, Q., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.0950 · Cited by 4,349 · see citing works
Wan, Y., Shang, J., Graham, R., Baric, R. S., & Li, F. (2020) · Journal of Virology · doi:10.1128/jvi.00127-20 · Cited by 4,341 · see citing works
Cardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019 (COVID-19)
Guo, T., Fan, Y., Chen, M., Wu, X., Zhang, L., He, T., Wang, H., Wan, J., Wang, X., & Lu, Z. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.1017 · Cited by 4,194 · see citing works
Structural basis of receptor recognition by SARS-CoV-2
Shang, J., Ye, G., Shi, K., Wan, Y., Luo, C., Aihara, H., Geng, Q., Auerbach, A., & Li, F. (2020) · Nature · doi:10.1038/s41586-020-2179-y · Cited by 3,661 · see citing works
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445 · see citing works
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149 · see citing works
Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M. L., Stagliano, N. E., Donovan, M. J., Woolf, B., Robison, K. E., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 3,084 · see citing works
Zhang, H., Penninger, J. M., Li, Y., Zhong, N., & Slutsky, A. S. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05985-9 · Cited by 2,684 · see citing works
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453 · see citing works
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
Wu, A., Peng, Y., Huang, B., Ding, X. L., Wang, X., Niu, P., Meng, J., Zhu, Z., Zhang, Z., Wang, J., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.02.001 · Cited by 2,363 · see citing works
STUDIES ON EXPERIMENTAL HYPERTENSION
Goldblatt, H., Lynch, J., Hanzal, R. F., & Summerville, W. W. (1934) · The Journal of Experimental Medicine · doi:10.1084/jem.59.3.347 · Cited by 2,145 · see citing works
Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19
Vaduganathan, M., Vardeny, O., Michel, T., McMurray, J. J. V., Pfeffer, M. A., & Solomon, S. D. (2020) · New England Journal of Medicine · doi:10.1056/nejmsr2005760 · Cited by 2,101 · see citing works
Liu, Y., Yang, Y., Zhang, C., Huang, F., Wang, F., Yuan, J., Wang, Z., Li, J., Li, J., Feng, C., et al. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1643-8 · Cited by 2,037 · see citing works
A Human Homolog of Angiotensin-converting Enzyme
Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,032 · see citing works
Self-citationStructure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor
Li, F., Li, W., Farzan, M., & Harrison, S. C. (2005) · Science · doi:10.1126/science.1116480 · Cited by 2,031 · see citing works
Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)
Inciardi, R. M., Lupi, L., Zaccone, G., Italia, L., Raffo, M., Tomasoni, D., Cani, D., Cerini, M., Farina, D., Gavazzi, E., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.1096 · Cited by 1,860 · see citing works
Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
Santos, R. A. S., Silva, A. C. S. E., Maric, C., Silva, D. M. R., Machado, R. P., de Buhr, I., Heringer‐Walther, S., Pinheiro, S. V. B., Lopes, M. T., Bäder, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432869100 · Cited by 1,805 · see citing works
Coronaviruses post-SARS: update on replication and pathogenesis
Perlman, S. M., & Netland, J. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2147 · Cited by 1,766 · see citing works
COVID-19 and cardiovascular disease
Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., Jain, S. S., Burkhoff, D., Kumaraiah, D., Rabbani, L., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046941 · Cited by 1,738 · see citing works
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733 · see citing works
Self-citationCloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
Moss, M. L., Jin, S.-L. C., Milla, M. E., Burkhart, W., Carter, H. L., Chen, W., Clay, W. C., Didsbury, J. R., Hassler, D. F., Hoffman, C. R., et al. (1997) · Nature · doi:10.1038/385733a0 · Cited by 1,611 · see citing works
Emerging Pathogenic Links Between Microbiota and the Gut-Lung Axis
Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.142 · Cited by 1,606 · see citing works
Ferrario, C. M., Jessup, J. A., Chappell, M. C., Averill, D. B., Brosnihan, K. B., Tallant, E. A., Diz, D. I., & Gallagher, P. E. (2005) · Circulation · doi:10.1161/circulationaha.104.510461 · Cited by 1,567 · see citing works
Prolonged presence of SARS-CoV-2 viral RNA in faecal samples
Wu, Y., Guo, C., Tang, L., Hong, Z., Zhou, J., Dong, X., Yin, H., Xiao, Q., Tang, Y., Qu, X., et al. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30083-2 · Cited by 1,550 · see citing works
Multiple organ infection and the pathogenesis of SARS
Gu, J., Gong, E., Zhang, B., Zheng, J., Gao, Z., Zhong, Y., Zou, W., Zhan, J., Wang, S., Xie, Z., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050828 · Cited by 1,379 · see citing works
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271 · see citing works
Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152 · see citing works
Ding, Y., He, L., Zhang, Q., Huang, Z., Che, X., Hou, J., Wang, H., Shen, H., Qiu, L., Li, Z., et al. (2004) · The Journal of Pathology · doi:10.1002/path.1560 · Cited by 1,068 · see citing works
THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
Skeggs, L. T., Kahn, J. R., & Shumway, N. P. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.103.3.295 · Cited by 1,035 · see citing works
SARS‐coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS
Oudit, G. Y., Kassiri, Z., Jiang, C., Liu, P. P., Poutanen, S. M., Penninger, J. M., & BUTANY, J. W. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02153.x · Cited by 896 · see citing works
Self-citationHost cell proteases: Critical determinants of coronavirus tropism and pathogenesis
Millet, J. K., & Whittaker, G. R. (2014) · Virus Research · doi:10.1016/j.virusres.2014.11.021 · Cited by 888 · see citing works
Role of the ACE2/angiotensin 1-7 axis of the renin-angiotensin system in heart failure
Patel, V. B., Zhong, J.-C., Grant, M. B., & Oudit, G. Y. (2016) · Circulation Research · doi:10.1161/circresaha.116.307708 · Cited by 833 · see citing works
Self-citationHofmann, H., Pyrc, K., van der Hoek, L., Geier, M., Berkhout, B., & Pöhlmann, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409465102 · Cited by 824 · see citing works
Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?
Yeo, C., Sanghvi, K., & Yeo, D. X. W. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30048-0 · Cited by 818 · see citing works
Wang, H., Yang, P., Liu, K., Guo, F., Zhang, Y., Zhang, G., & Jiang, C. (2008) · Cell Research · doi:10.1038/cr.2008.15 · Cited by 700 · see citing works
Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection
Leung, W. K., To, K., Chan, P. K. S., Chan, H. L., Wu, A. K. L., Lee, N. L. S., Yuen, K., & Sung, J. J. �. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01215-0 · Cited by 697 · see citing works
Lambert, D., Yarski, M., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., Hooper, N. M., & Turner, A. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505111200 · Cited by 697 · see citing works
Self-citationPacker, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.509 · Cited by 656 · see citing works
Rice, G., Thomas, D. A., Grant, P. J., Turner, A. J., & Hooper, N. M. (2004) · Biochemical Journal · doi:10.1042/bj20040634 · Cited by 619 · see citing works
Self-citationKhan, A., Benthin, C., Zeno, B. R., Albertson, T. E., Boyd, J. H., Christie, J. D., Hall, R., Poirier, G., Ronco, J. J., Tidswell, M., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1823-x · Cited by 600 · see citing works
Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease.
McIntosh, K., Dees, J. H., Becker, W. B., Kapikian, A. Z., & Chanock, R. M. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.4.933 · Cited by 589 · see citing works
Ishiyama, Y., Gallagher, P. E., Averill, D. B., Tallant, E. A., Brosnihan, K. B., & Ferrario, C. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000124667.34652.1a · Cited by 564 · see citing works
Sampaio, W. O., Santos, R. A. S., Faria-Silva, R., Machado, L. T., Schiffrin, E. L., & Touyz, R. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000251865.35728.2f · Cited by 563 · see citing works
Hypertension-Linked Pathophysiological Alterations in the Gut
Santisteban, M. M., Qi, Y., Zubcevic, J., Kim, S., Yang, T., Shenoy, V., Cole-Jeffrey, C. T., Lobaton, G. O., Stewart, D. C., Rubiano, A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.309006 · Cited by 525 · see citing works
Self-citationHaga, S., Yamamoto, N., Nakai-Murakami, C., Osawa, Y., Tokunaga, K., Sata, T., Yamamoto, N., Sasazuki, T., & Ishizaka, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711241105 · Cited by 522 · see citing works
ACE2: from vasopeptidase to SARS virus receptor
Turner, A. J., Hiscox, J. A., & Hooper, N. M. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.04.001 · Cited by 517 · see citing works
Self-citationKuba, K., Imai, Y., Ohto‐Nakanishi, T., & Penninger, J. M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.06.003 · Cited by 480 · see citing works
ADAMs: focus on the protease domain
Black, R. A., & White, J. M. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80042-2 · Cited by 467 · see citing works
Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks
Semple, B. D., Kossmann, T., & Morganti-Kossmann, M. C. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.240 · Cited by 457 · see citing works
Zhong, J., Basu, R., Guo, D., Chow, F. L., Byrns, S., Schuster, M., Loibner, H., Wang, X., Penninger, J. M., Kassiri, Z., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.955369 · Cited by 457 · see citing works
Self-citationMyocardial infarction increases ACE2 expression in rat and humans
Burrell, L. M., Risvanis, J., Kubota, E., Dean, R. G., Macdonald, P. S., Lu, L., Tikellis, C., Grant, S. L., Lew, R. A., Smith, A. I., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi114 · Cited by 423 · see citing works
ADAM-17: the enzyme that does it all
Gooz, M. B. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409231003628015 · Cited by 413 · see citing works
Age- and gender-related difference of ACE2 expression in rat lung
Xudong, X., Junzhu, C., Xingxiang, W., Furong, Z., & Yanrong, L. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.09.038 · Cited by 410 · see citing works
Navigating the Crossroads of Coronary Artery Disease and Heart Failure
Gheorghiade, M., Sopko, G. S., Luca, L. D., Velazquez, E. J., Parker, J. D., Binkley, P. F., Sadowski, Z., Golba, K. S., Prior, D., Rouleau, J. L., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.623199 · Cited by 400 · see citing works
SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19?
Kuster, G. M., Pfister, O., Burkard, T., Zhou, Q., Twerenbold, R., Haaf, P., Widmer, A. F., & Osswald, S. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa235 · Cited by 395 · see citing works
Zhou, J., Li, C., Zhao, G., Chu, H., Wang, D., Yan, H. H.-N., Poon, V. K., Wen, L., Wong, B. H., Zhao, X., et al. (2017) · Science Advances · doi:10.1126/sciadv.aao4966 · Cited by 376 · see citing works
Beli, E., Yan, Y., Moldovan, L., Vieira, C. P., Gao, R., Duan, Y., Prasad, R., Bhatwadekar, A. D., White, F. A., Townsend, S. D., et al. (2018) · Diabetes · doi:10.2337/db18-0158 · Cited by 369 · see citing works
Self-citationCharacterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy
Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W. C., Burrell, L. M., Risvanis, J., & Cooper, M. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000060689.38912.cb · Cited by 349 · see citing works
Novel Role for the Potent Endogenous Inotrope Apelin in Human Cardiac Dysfunction
Chen, M. M., Ashley, E. A., Deng, D. X.-F., Tsalenko, A., Deng, A. C., Tabibiazar, R., Ben‐Dor, A., Fenster, B. E., Yang, E., King, J. Y., et al. (2003) · Circulation · doi:10.1161/01.cir.0000091235.94914.75 · Cited by 349 · see citing works
The renin-angiotensin system: going beyond the classical paradigms
Santos, R. A. S., Oudit, G. Y., Verano‐Braga, T., Canta, G., Steckelings, U. M., & Bäder, M. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00723.2018 · Cited by 341 · see citing works
Self-citationViral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome
Cheng, P. K. C., Wong, D. A., Tong, L. K. L., Ip, S.-M., Lo, A. C. T., Lau, C. S., Yeung, E. Y. H., & Lim, W. W. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16255-7 · Cited by 332 · see citing works
Patel, V. B., Clarke, N. E., Wang, Z., Dong, F., Parajuli, N., Basu, R., Putko, B. N., Kassiri, Z., Turner, A. J., & Oudit, G. Y. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.017 · Cited by 321 · see citing works
Self-citationAngiotensin-(1–7) inhibits growth of cardiac myocytes through activation of themasreceptor
Tallant, E. A., Ferrario, C. M., & Gallagher, P. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00941.2004 · Cited by 317 · see citing works
Kuba, K., Zhang, L., Imai, Y., Arab, S., Chen, M., Maekawa, Y., Leschnik, M. W., Leibbrandt, A., Markovic, M., Schwaighofer, J., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.158659 · Cited by 309 · see citing works
Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2
Wysocki, J. A., Ye, M., Rodríguez, E., González‐Pacheco, F. R., Barrios, C., Evora, K., Schuster, M., Loibner, H., Brosnihan, K. B., Ferrario, C. M., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138420 · Cited by 300 · see citing works
Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy
Oudit, G. Y., Liu, G. C., Zhong, J., Basu, R., Chow, F. L., Zhou, J., Loibner, H., Janzek, E., Schuster, M., Penninger, J. M., et al. (2009) · Diabetes · doi:10.2337/db09-1218 · Cited by 298 · see citing works
Self-citationPulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease
Jia, H. (2016) · Shock · doi:10.1097/shk.0000000000000633 · Cited by 296 · see citing works
Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial Cells
Sampaio, W. O., Castro, C. H., Santos, R. A. S., Schiffrin, E. L., & Touyz, R. M. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.084848 · Cited by 283 · see citing works
Camargo, S. M. R., Singer, D., Makrides, V., Huggel, K., Pos, K. M., Wagner, C. A., Kuba, K., Danilczyk, U. G., Skovby, F., Kleta, R., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.055 · Cited by 282 · see citing works
Ocaranza, M. P., Godoy, I. E., Jalil, J., Varas‐Godoy, M., Collantes, P., Pinto, M., Román, M., Ramirez, C., Copaja, M., Dı́az-Araya, G., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000237862.94083.45 · Cited by 273 · see citing works
Koka, V., Huang, X. R., Chung, A. C. K., Wang, W., Truong, L. D., & Lan, H. Y. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070762 · Cited by 272 · see citing works
Angiotensin-Converting Enzyme II in the Heart and the Kidney
Danilczyk, U. G., & Penninger, J. M. (2006) · Circulation Research · doi:10.1161/01.res.0000205761.22353.5f · Cited by 271 · see citing works
Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury
Wong, D., Oudit, G. Y., Reich, H. N., Kassiri, Z., Zhou, J., Liu, Q. C., Backx, P. H., Penninger, J. M., Herzenberg, A. M., & Scholey, J. W. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060977 · Cited by 267 · see citing works
Self-citationAngiotensin Converting Enzyme 2: A Double-Edged Sword
Wang, K., Gheblawi, M., & Oudit, G. Y. (2020) · Circulation · doi:10.1161/circulationaha.120.047049 · Cited by 265 · see citing works
Self-citationFerrario, C. M., Jessup, J. A., Gallagher, P. E., Averill, D. B., Brosnihan, K. B., Tallant, E. A., Smith, R. D., & Chappell, M. C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00675.x · Cited by 259 · see citing works
Xu, P., & Derynck, R. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.034 · Cited by 257 · see citing works
Patel, V. B., Mori, J., McLean, B. A., Basu, R., Das, S. K., Ramprasath, T., Parajuli, N., Penninger, J. M., Grant, M. B., Lopaschuk, G. D., et al. (2015) · Diabetes · doi:10.2337/db15-0399 · Cited by 257 · see citing works
Self-citationThe Role of ACE2 in Cardiovascular Physiology
Oudit, G. Y., Crackower, M. A., Backx, P. H., & Penninger, J. M. (2003) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(02)00233-5 · Cited by 255 · see citing works
Self-citationDetection of Soluble Angiotensin-Converting Enzyme 2 in Heart Failure
Epelman, S., Tang, W. H. W., Chen, S. Y., Lente, F. V., Francis, G. S., & Sen, S. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.088 · Cited by 251 · see citing works
Reich, H. N., Oudit, G. Y., Penninger, J. M., Scholey, J. W., & Herzenberg, A. M. (2008) · Kidney International · doi:10.1038/ki.2008.497 · Cited by 249 · see citing works
Self-citationOudit, G. Y., Kassiri, Z., PATEL, M., Chappell, M. C., BUTANY, J. W., Backx, P. H., Tsushima, R. G., Scholey, J. W., Khokha, R., & Penninger, J. M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.007 · Cited by 247 · see citing works
Self-citationDiabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock
Busik, J. V., Tikhonenko, M., Bhatwadekar, A. D., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090889 · Cited by 242 · see citing works
Impairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout Mice
Santos, R. A. S., Castro, C. H., Gava, E., Pinheiro, S. V. B., Almeida, A. P., de Paula, R. D., Cruz, J. S., Ramos, A. S., Rosa, K. T., Irigoyen, M. C., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000215289.51180.5c · Cited by 237 · see citing works
Zhong, J., Guo, D., Chen, C. B., Wang, W., Schuster, M., Loibner, H., Penninger, J. M., Scholey, J. W., Kassiri, Z., & Oudit, G. Y. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.164244 · Cited by 234 · see citing works
Self-citationIwata, M., Cowling, R. T., Gurantz, D., Moore, C., Zhang, S., Yuan, J. X.-J., & Greenberg, B. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00317.2005 · Cited by 231 · see citing works
Angiotensin AT 1 Receptor Subtype as a Cardiac Target of Aldosterone
Robert, V., Heymes, C., Silvestre, J., Sabri, A., Bernard Swynghedauw, A., & Delcayre, C. (1999) · Hypertension · doi:10.1161/01.hyp.33.4.981 · Cited by 230 · see citing works
Thomas, M. C., Pickering, R. J., Tsorotes, D., Koı̈tka, A., Sheehy, K., Bernardi, S., Toffoli, B., Nguyen‐Huu, T., Head, G. A., Fu, Y., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.219279 · Cited by 230 · see citing works
Iyer, S. N., Ferrario, C. M., & Chappell, M. C. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.356 · Cited by 228 · see citing works
Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart
Mercure, C., Yogi, Á., Callera, G. E., Aranha, A. B., Bäder, M., Ferreira, A. J., Santos, R. A. S., Walther, T., Touyz, R. M., & Reudelhuber, T. L. (2008) · Circulation Research · doi:10.1161/circresaha.108.184911 · Cited by 226 · see citing works
Kassiri, Z., Zhong, J., Guo, D., Basu, R., Wang, X., Liu, P. P., Scholey, J. W., Penninger, J. M., & Oudit, G. Y. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.840124 · Cited by 226 · see citing works
Self-citationAngiotensin‐Converting Enzyme 2: The First Decade
Clarke, N. E., & Turner, A. J. (2011) · International Journal of Hypertension · doi:10.1155/2012/307315 · Cited by 225 · see citing works
Self-citationHemnes, A. R., Rathinasabapathy, A., Austin, E. A., Brittain, E. L., Carrier, E. J., Chen, X., Fessel, J. P., Fike, C. D., Fong, P., Fortune, N. L., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.02638-2017 · Cited by 221 · see citing works
Wang, W., McKinnie, S. M. K., Patel, V. B., Haddad, G., Wang, Z., Zhabyeyev, P., Das, S. K., Basu, R., McLean, B. A., Kandalam, V., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000249 · Cited by 219 · see citing works
Self-citationPatel, V. B., Shah, S., Verma, S., & Oudit, G. Y. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9644-1 · Cited by 218 · see citing works
Self-citationAltered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension
Kim, S., Rigatto, K., Gazzana, M. B., Knorst, M. M., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14294 · Cited by 216 · see citing works
Self-citationHarada, E., Yoshimura, M., Yasue, H., Nakagawa, O., Nakagawa, M., Harada, M., Mizuno, Y., Nakayama, M., Shimasaki, Y., Ito, T., et al. (2001) · Circulation · doi:10.1161/01.cir.104.2.137 · Cited by 211 · see citing works
Chappell, M. C. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.076216 · Cited by 206 · see citing works
Chong, K. S., Gardner, R. S., Morton, J. J., et al. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.10.007 · Cited by 205 · see citing works
Ye, R., & Liu, Z. (2019) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2019.104350 · Cited by 205 · see citing works
Igase, M., Strawn, W. B., Gallagher, P. E., Geary, R. L., & Ferrario, C. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00068.2005 · Cited by 203 · see citing works
ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR
Díez-Freire, C., Vázquez, J., de Adjounian, M. F. C., Ferrari, M., Yuan, L., Silver, X., Torres, R., & Raizada, M. K. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00312.2005 · Cited by 200 · see citing works
Self-citationSoler, M. J., Ye, M., Wysocki, J. A., William, J., Lloveras, J., & BATLLE, D. C. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90488.2008 · Cited by 199 · see citing works
Pitkin, S. L., Maguire, J. J., Bonner, T. I., & Davenport, A. P. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002949 · Cited by 198 · see citing works
Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure
Basu, R., Poglitsch, M., Yogasundaram, H., Thomas, J., Rowe, B. H., & Oudit, G. Y. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.064 · Cited by 197 · see citing works
Self-citationKeidar, S., Gamliel-Lazarovich, A., Kaplan, M., Pavlotzky, E., Hamoud, S., Hayek, T., Karry, R., & Abassi, Z. A. (2005) · Circulation Research · doi:10.1161/01.res.0000187500.24964.7a · Cited by 196 · see citing works
CCL2/MCP-1 modulation of microglial activation and proliferation
Hinojosa, A. E., García‐Bueno, B., Leza, J. C., & Madrigal, J. L. M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-77 · Cited by 195 · see citing works
Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents
Gembardt, F., Sterner‐Kock, A., Imboden, H., Spalteholz, M., Reibitz, F., Schultheiß, H., Siems, W., & Walther, T. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.009 · Cited by 190 · see citing works
Mori, J., Patel, V. B., Alrob, O. A., Basu, R., Altamimi, T., DesAulniers, J., Wagg, C. S., Kassiri, Z., Lopaschuk, G. D., & Oudit, G. Y. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000672 · Cited by 190 · see citing works
Self-citationAngiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17
Wang, W., McKinnie, S. M. K., Farhan, M., Paul, M., McDonald, T. R., McLean, B. A., Llorens‐Cortés, C., Hazra, S., Murray, A. G., Vederas, J. C., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06892 · Cited by 190 · see citing works
Self-citationApelin is a positive regulator of ACE2 in failing hearts
Sato, T., SUZUKI, T. A., Watanabe, H., Kadowaki, A., Fukamizu, A., Liu, P. P., Kimura, A., Ito, H., Penninger, J. M., Imai, Y., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69608 · Cited by 188 · see citing works
Rentzsch, B., Todiraş, M., Iliescu, R., Popova, E., Campos, L. A., Oliveira, M. L., Baltatu, O. C., Santos, R. A. S., & Bäder, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114322 · Cited by 187 · see citing works
Xia, H., Sriramula, S., Chhabra, K. H., & Lazartigues, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.301811 · Cited by 173 · see citing works
Xu, J., Sriramula, S., Xia, H., Moreno-Walton, L. A., Culicchia, F., Domenig, O., Poglitsch, M., & Lazartigues, E. D. (2017) · Circulation Research · doi:10.1161/circresaha.116.310509 · Cited by 171 · see citing works
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging
Qi, Y., Goel, R., Kim, S., Richards, E. M., Carter, C. S., Pepine, C. J., Raizada, M. K., & Buford, T. W. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.018 · Cited by 165 · see citing works
Self-citationACE2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy
Verma, A., Shan, Z. J., Lei, B., Yuan, L., Liu, X., Nakagawa, T., Grant, M. B., Lewin, A. S., Hauswirth, W. W., Raizada, M. K., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.155 · Cited by 159 · see citing works
Self-citationACE2, angiotensin-(1–7), and Mas: the other side of the coin
Bäder, M. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1120-0 · Cited by 158 · see citing works
Patel, V. B., Bodiga, S., Basu, R., Das, S. K., Wang, W., Wang, Z., Lo, J., Grant, M. B., Zhong, J., Kassiri, Z., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.268029 · Cited by 155 · see citing works
Self-citationShenoy, V., Kwon, K., Rathinasabapathy, A., Lin, S., Jin, G., Song, C., Shil, P. K., Nair, A. R., Qi, Y., Li, Q., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03871 · Cited by 142 · see citing works
Self-citationGenetically altered animal models for Mas and angiotensin‐(1–7)
Alenina, N. V., Xu, P., Rentzsch, B., Patkin, E. L., & Bäder, M. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.040345 · Cited by 142 · see citing works
The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans‐inhibition
Siddiquee, K., Hampton, J., McAnally, D., May, L. T., & Smith, L. H. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02192.x · Cited by 141 · see citing works
Huang, D., Wujek, J. R., Kidd, G. J., He, T. T., Cardona, A. E., Sasse, M. E., Stein, E. J., Kish, J., Tani, M., Charo, I. F., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3104com · Cited by 140 · see citing works
Patel, S. K., Velkoska, E., Freeman, M., Wai, B., Lancefield, T. F., & Burrell, L. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00227 · Cited by 138 · see citing works
Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension
Sharma, R. K., Yang, T., Oliveira, A. C. D. S., Lobaton, G. O., Aquino, V. P., Kim, S., Richards, E. M., Pepine, C. J., Sumners, C., & Raizada, M. K. (2019) · Circulation Research · doi:10.1161/circresaha.118.313882 · Cited by 137 · see citing works
Self-citationMori, J., Patel, V. B., Ramprasath, T., Alrob, O. A., DesAulniers, J., Scholey, J. W., Lopaschuk, G. D., & Oudit, G. Y. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00655.2013 · Cited by 130 · see citing works
Self-citationJessup, J. A., Gallagher, P. E., Averill, D. B., Brosnihan, K. B., Tallant, E. A., Chappell, M. C., & Ferrario, C. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00061.2006 · Cited by 128 · see citing works
Santisteban, M. M., Kim, S., Pepine, C. J., & Raizada, M. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.307709 · Cited by 126 · see citing works
Self-citationMicrobiome and diabetes: Where are we now?
Vallianou, N. G., Stratigou, T., & Tsagarakis, S. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.10.008 · Cited by 126 · see citing works
Genetically engineered probiotics
Steidler, L. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00072-6 · Cited by 120 · see citing works
Structural and Functional Analysis of the Surface Protein of Human Coronavirus OC43
Künkel, F., & Herrler, G. (1993) · Virology · doi:10.1006/viro.1993.1360 · Cited by 119 · see citing works
CCL5 induces a pro-inflammatory profile in microglia in vitro
Škuljec, J., Sun, H., Pul, R., Bénardais, K., Ragancokova, D., Moharregh-Khiabani, D., Kotsiari, A., Trebst, C., & Stangel, M. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.05.001 · Cited by 118 · see citing works
Scott, A. J., O'Dea, K. P., O'Callaghan, D., Williams, L. M., Dokpesi, J. O., Tatton, L., Handy, J. M., Hogg, P. J., & Takata, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277434 · Cited by 118 · see citing works
Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling
Dell’Italia, L. J., Collawn, J. F., & Ferrario, C. M. (2018) · Circulation Research · doi:10.1161/circresaha.117.310978 · Cited by 113 · see citing works
Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury
Rey-Parra, G., Vadivel, A., Coltan, L., Hall, A., Eaton, F., Schuster, M., Loibner, H., Penninger, J. M., Kassiri, Z., Oudit, G. Y., et al. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0859-2 · Cited by 112 · see citing works
Self-citationPage, I. H., & Helmer, O. M. (1940) · The Journal of Experimental Medicine · doi:10.1084/jem.71.4.495 · Cited by 109 · see citing works
Iyer, S. N., Lu, D., Katovich, M. J., & Raizada, M. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9960 · Cited by 108 · see citing works
Self-citationTargeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases
Zhong, J., Zhang, Z.-Z., Wang, W., McKinnie, S. M. K., Vederas, J. C., & Oudit, G. Y. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.007 · Cited by 108 · see citing works
Self-citationTreml, B., Neu, N., Kleinsasser, A. T., Gritsch, C., Finsterwalder, T., Geiger, R., Schuster, M., Janzek, E., Loibner, H., Penninger, J. M., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c03009 · Cited by 107 · see citing works
Zhang, Z.-Z., Wang, W., Jin, H., Chen, X., Cheng, Y., Xu, Y., Song, B., Penninger, J. M., Oudit, G. Y., & Zhong, J. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.10156 · Cited by 107 · see citing works
Self-citationFlores‐Muñoz, M., Work, L. M., Douglas, K. B., Denby, L., Dominiczak, A. F., Graham, D., & Nicklin, S. A. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.177485 · Cited by 105 · see citing works
Patel, V. B., Bodiga, S., Dong, F., Das, S. K., Wang, Z., Wang, W., Basu, R., Zhong, J., Kassiri, Z., & Oudit, G. Y. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.191650 · Cited by 104 · see citing works
Self-citationJarajapu, Y. P. R., Bhatwadekar, A. D., Caballero, S., Hazra, S., Shenoy, V., Medina, R. J., Kent, D., Stitt, A. W., Thut, C. J., Finney, E. M., et al. (2012) · Diabetes · doi:10.2337/db12-0808 · Cited by 104 · see citing works
Self-citationPatel, V. B., Basu, R., & Oudit, G. Y. (2016) · Adipocyte · doi:10.1080/21623945.2015.1131881 · Cited by 103 · see citing works
Self-citationCole‐Jeffrey, C. T., Liu, M., Katovich, M. J., Raizada, M. K., & Shenoy, V. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000307 · Cited by 103 · see citing works
Self-citationExpression of Human ACE2 in Lactobacillus and Beneficial Effects in Diabetic Retinopathy in Mice
Verma, A., Xu, K., Du, T., Zhu, P., Liang, Z., Liao, S., Zhang, J., Raizada, M. K., Grant, M. B., & Li, Q. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.06.007 · Cited by 102 · see citing works
Self-citationRole of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications
Patel, V. B., Parajuli, N., & Oudit, G. Y. (2013) · Clinical Science · doi:10.1042/cs20130344 · Cited by 98 · see citing works
Self-citationPatel, V. B., Zhong, J., Dong, F., Basu, R., Morton, J. S., Parajuli, N., McMurtry, M. S., Davidge, S. T., Kassiri, Z., & Oudit, G. Y. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03388 · Cited by 97 · see citing works
Self-citationAngiotensin-(1–9) regulates cardiac hypertrophy in vivo and in vitro
Ocaranza, M. P., Lavandero, S., Jalil, J., Moya, J., Pinto, M., Novoa, U., Apablaza, F., González, L., Hernández, C., Varas‐Godoy, M., et al. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328335d291 · Cited by 96 · see citing works
Schilling, M., Strecker, J., Ringelstein, E. B., Schäbitz, W., & Kiefer, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.054 · Cited by 95 · see citing works
ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons
Mukerjee, S., Gao, H., Xu, J., Sato, R., Zsombok, A., & Lazartigues, E. D. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13133 · Cited by 92 · see citing works
Duan, Y., Prasad, R., Feng, D., Beli, E., Calzi, S. L., Longhini, A. L. F., Lamendella, R., Floyd, J. L., Dupont, M., Noothi, S. K., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315743 · Cited by 92 · see citing works
Self-citationHazra, S., Jarajapu, Y. P. R., Stepps, V., Caballero, S., Thinschmidt, J. S., Sautina, L., Bengtsson, N. E., LiCalzi, S., Dominguez, J. M., Kern, T. S., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2781-0 · Cited by 84 · see citing works
Self-citationJin, H., Song, B., Oudit, G. Y., Davidge, S. T., Yu, H., Jiang, Y., Gao, P., Zhu, D., Ning, G., Kassiri, Z., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038502 · Cited by 83 · see citing works
Self-citationWang, Y., Qian, C., Roks, A. J. M., Westermann, D., Schumacher, S.-M., Escher, F., Schoemaker, R. G., Reudelhuber, T. L., van Gilst, W. H., Schultheiß, H., et al. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.905968 · Cited by 81 · see citing works
TAKEDA, Y., ZHU, A., YONEDA, T., Usukura, M., TAKATA, H., & YAMAGISHI, M. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.05.008 · Cited by 77 · see citing works
Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction
Przewłocka‐Kosmala, M., Kotwica, T., Mysiak, A., & Kosmala, W. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328344da76 · Cited by 76 · see citing works
Kawabe, Y., Mori, J., Morimoto, H., Yamaguchi, M., Miyagaki, S., Ota, T., Tsuma, Y., Fukuhara, S., Nakajima, H., Oudit, G. Y., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00311.2019 · Cited by 74 · see citing works
Self-citationOptimizing Treatment of Hypertension in Patients With Diabetes
Cooper, M. E. (2000) · JAMA · doi:10.1001/jama.283.24.3177 · Cited by 71 · see citing works
Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm
Shen, M., Hu, M., Fedak, P. W. M., Oudit, G. Y., & Kassiri, Z. (2018) · Circulation Research · doi:10.1161/circresaha.118.313181 · Cited by 70 · see citing works
Self-citationOudit, G. Y., & Penninger, J. M. (2011) · Current Heart Failure Reports · doi:10.1007/s11897-011-0063-7 · Cited by 67 · see citing works
Self-citationLo, J., Patel, V. B., Wang, Z., Levasseur, J. L., Kaufman, S., Penninger, J. M., & Oudit, G. Y. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.067165 · Cited by 64 · see citing works
Self-citationLo, C., Liu, F., Shi, Y., Maachi, H., Chénier, I., Godin, N., Filep, J. G., Ingelfinger, J. R., Zhang, S., & Chan, J. S. D. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00340.2011 · Cited by 63 · see citing works
Angiotensin 1–7 stimulates brown adipose tissue and reduces diet-induced obesity
Morimoto, H., Mori, J., Nakajima, H., Kawabe, Y., Tsuma, Y., Fukuhara, S., Kodo, K., Ikoma, K., Matoba, S., Oudit, G. Y., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00192.2017 · Cited by 63 · see citing works
Self-citationWang, W., Shen, M., Fischer, C., Basu, R., Hazra, S., Couvineau, P., Paul, M., Wang, F., Toth, S., Mix, D., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900152116 · Cited by 63 · see citing works
Self-citationYilin, Z., Yandong, N., & Jin, F. (2015) · Burns · doi:10.1016/j.burns.2015.04.010 · Cited by 62 · see citing works
Ocaranza, M. P., Rivera, P., Novoa, U., Pinto, M., González, L., Chiong, M., Lavandero, S., & Jalil, J. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283440665 · Cited by 61 · see citing works
Qi, Y. F., Zhang, J., Wang, L., Shenoy, V., Krause, E. G., Oh, S. P., Pepine, C. J., Katovich, M. J., & Raizada, M. K. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1356-1 · Cited by 59 · see citing works
Self-citationFlores‐Muñoz, M., Godinho, B. M. D. C., Almalik, A., & Nicklin, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045564 · Cited by 58 · see citing works
Tikellis, C., Pickering, R., Tsorotes, D., Du, X.-J., Kiriazis, H., Nguyen-Huu, T.-P., Head, G. A., Cooper, M. E., & Thomas, M. C. (2012) · Clinical Science · doi:10.1042/cs20110668 · Cited by 57 · see citing works
Dominguez, J. M., Hu, P., Caballero, S., Moldovan, L., Verma, A., Oudit, G. Y., Li, Q., & Grant, M. B. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.01.023 · Cited by 55 · see citing works
Self-citationOntogeny of angiotensin-converting enzyme 2
Song, R., Preston, G. J., & Yosypiv, I. V. (2011) · Pediatric Research · doi:10.1038/pr.2011.7 · Cited by 53 · see citing works
Bae, E. H., Fang, F., Williams, V. R., et al. (2017) · Kidney International · doi:10.1016/j.kint.2016.12.022 · Cited by 51 · see citing works
Dong, F., Takawale, A. R., Shen, M., Wang, W., Wang, X., Basu, R., Oudit, G. Y., & Kassiri, Z. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.002029 · Cited by 49 · see citing works
Self-citationYamamuro, M., Yoshimura, M., Nakayama, M., Abe, K., Sumida, H., Sugiyama, S., Saito, Y., Nakao, K., Yasue, H., & Ogawa, H. (2008) · Circulation Journal · doi:10.1253/circj.72.1346 · Cited by 47 · see citing works
Diminazene aceturate improves autonomic modulation in pulmonary hypertension
Rigatto, K., Casali, K. R., Shenoy, V., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.017 · Cited by 47 · see citing works
Antagonism of angiotensin 1–7 prevents the therapeutic effects of recombinant human ACE2
Patel, V. B., Takawale, A. R., Ramprasath, T., Das, S. K., Basu, R., Grant, M. B., Hall, D. A., Kassiri, Z., & Oudit, G. Y. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1285-z · Cited by 45 · see citing works
Self-citationChen, Y., Wang, X., Yang, C., Su, X., Yang, W., Dai, Y., Han, H., Jiang, J., Lu, L., Wang, H., et al. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.025 · Cited by 44 · see citing works
Aldosterone increases VEGF-A production in human neutrophils through PI3K, ERK1/2 and p38 pathways
Walczak, C., Gaignier, F., Gilet, A., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.07.010 · Cited by 43 · see citing works
Lactic Acid Bacteria for Delivery of Endogenous or Engineered Therapeutic Molecules
Bron, P. A., & Kleerebezem, M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01821 · Cited by 43 · see citing works
Pulmonary hypertension: Pathophysiology beyond the lung
Oliveira, A. C. D. S., Richards, E. M., & Raizada, M. K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104518 · Cited by 43 · see citing works
Self-citationSix Truisms Concerning ACE and the Renin-Angiotensin System Educed From the Genetic Analysis of Mice
Bernstein, K. E., Xiao, H., Frenzel, K. E., Li, P., Shen, X. Z., Adams, J. W., & Fuchs, S. (2005) · Circulation Research · doi:10.1161/01.res.0000169536.73576.66 · Cited by 42 · see citing works
Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease
Wang, W., Patel, V. B., Parajuli, N., Dong, F., Basu, R., Wang, Z., Ramprasath, T., Kassiri, Z., Penninger, J. M., & Oudit, G. Y. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1149-y · Cited by 41 · see citing works
Self-citationQi, Y., Kim, S., Richards, E. M., Raizada, M. K., & Pepine, C. J. (2017) · Circulation Research · doi:10.1161/circresaha.117.310734 · Cited by 41 · see citing works
Self-citationda Silva, J. S., Gabriel‐Costa, D., Wang, H., Ahmad, S., Sun, X., Varagić, J., Sudo, R. T., Ferrario, C. M., Italia, L. J. D., Zapata‐Sudo, G., et al. (2017) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320317722270 · Cited by 37 · see citing works
Fu, G., Xu, C., Zhong, Y., et al. (2012) · Endocrine · doi:10.1007/s12020-012-9675-2 · Cited by 29 · see citing works
Alteration of Cardiac ACE2/Mas Expression and Cardiac Remodelling in Rats with Aortic Constriction
Zhang, Y. (2014) · The Chinese Journal of Physiology · doi:10.4077/cjp.2014.bad268 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Aging in COVID-19: Vulnerability, immunity and intervention
Chen, Y., Klein, S. L., Garibaldi, B. T., Li, H., Wu, C., Osevala, N. M., Li, T., Margolick, J. B., Pawelec, G., & Leng, S. X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101205 · Cited by 1,007 · see citing works
Kell, D. B., Heyden, E. L., & Pretorius, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01221 · Cited by 460 · see citing works
COVID-19 cytokine storm: the anger of inflammation
Mahmudpour, M., Roozbeh, J., Keshavarz, M., Farrokhi, S., & Nabipour, I. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155151 · Cited by 461 · see citing works
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications
Drucker, D. J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa011 · Cited by 399 · see citing works
Systematic Review of COVID-19 Related Myocarditis: Insights on Management and Outcome
Sawalha, K., Abozenah, M., Kadado, A. J., Battisha, A., Al-Akchar, M., Salerno, C., Hernandez-Montfort, J., & Islam, A. M. (2021) · Cardiovascular Revascularization Medicine · doi:10.1016/j.carrev.2020.08.028 · Cited by 217 · see citing works
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
Rysz, S., Al-Saadi, J., Sjöström, A., Farm, M., Campoccia Jalde, F., Plattén, M., Eriksson, H., Klein, M., Vargas-Paris, R., Nyrén, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22713-z · Cited by 111 · see citing works
Yin, X.-X., Zheng, X.-R., Peng, W., Wu, M.-L., & Mao, X.-Y. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00294 · Cited by 72 · see citing works
Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19
Li, X., Zhang, Z., Wang, Z., Gutiérrez-Castrellón, P., & Shi, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01043-6 · Cited by 67 · see citing works
Renin–angiotensin system: Basic and clinical aspects—A general perspective
Vargas Vargas, R. A., Varela Millán, J. M., & Fajardo Bonilla, E. (2022) · Endocrinología, Diabetes y Nutrición (English ed.) · doi:10.1016/j.endien.2022.01.005 · Cited by 51 · see citing works
Chen, H., Peng, J., Wang, T., Wen, J., Chen, S., Huang, Y., & Zhang, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115370 · Cited by 19 · see citing works
Insights in Chloroquine Action: Perspectives and Implications in Malaria and <scp>COVID</scp>‐19
Pillat, M. M., Krüger, A., Guimarães, L. M. F., Lameu, C., de Souza, E. E., Wrenger, C., & Ulrich, H. (2020) · Cytometry Part A · doi:10.1002/cyto.a.24190 · Cited by 17 · see citing works
Mansour, H. M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102195 · Cited by 3 · see citing works
- Authors
- Gheblawi, M., Wang, K., Viveiros, A., Nguyen, Q., Zhong, J.-C., Turner, A. J., Raizada, M. K., Grant, M. B., & Oudit, G. Y.
- Affiliations
- University of Alberta (CA)
- Capital Medical University (CN)
- University of Leeds (GB)
- University of Florida (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Gheblawi, Mahmoud
- Wang, Kaiming
- ORCID
- Venue
- Circulation Research
- Published
- 2020-05-08
- Volume
- 126
- Issue
- 10
- Pages
- 1456-1474
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC7188049
- OpenAlex
- W3014571869
- Cited by
- 1,882
- References
- 201
- Citations by year
- 2026: 51 · 2025: 90 · 2024: 136 · 2023: 221 · 2022: 329 · 2021: 602 · 2020: 449 · 2019: 1
- FWCI
- 67.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL110170, R01HL102033)
- National Eye Institute (R01EY028037, R01EY028858, P30EY003039)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- angiotensin-converting enzyme 2, SARS-CoV-2 receptor, renin-angiotensin system, COVID-19 pandemic, angiotensin II, angiotensin-(1-7), receptor internalization, proteolytic cleavage, amino acid transport, gut dysbiosis, vascular permeability, pulmonary hypertension, cardiovascular complications of diabetes, heart failure, hypertension, myocardial infarction
- MeSH terms
- ADAM17 Protein, Betacoronavirus, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Animals, Cardiovascular Diseases, Humans, Peptidyl-Dipeptidase A, Pneumonia, Viral, Receptors, Virus, Renin-Angiotensin System, Coronavirus Infections, Diabetes Complications, Virus Attachment, Pandemics, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
