The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
Open accessAbstract
Diffuse hepatic cirrhosis develops in rats on a choline-deficient diet within 300 days. Absorbable broad spectrum antibiotics added to the daily diet do not prevent the development of fatty infiltration, but they delay the development of cirrhosis for about 100 days more. Non-absorbable antibiotics added to the daily diet prevent the development of cirrhosis in most rats for as long as 750 days. The superiority of non-absorbable antibiotics to absorbable antibiotics excludes a systemic effect of the antibiotics and demonstrates that intestinal bacteria are largely, if not wholly, responsible for the cirrhosis in rats on a choline-deficient diet.
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“There is strong evidence for an important contribution of the microbiota–TLR4 axis to liver fibrosis.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [72]
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“Studies from the past six decades have shown that antibiotics prevent hepatic injury and fibrosis induced by CCl4 treatment, bile duct ligation or a choline-deficient diet, and that endotoxin enhances hepatic fibrosis induced by a choline-deficient diet71–73.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [72]
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Citations
Cites
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Copeland, D. H., & Salmon, W. D. (1946) · PubMed · Cited by 150
Lectures on the Liver and its Diseases
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Griffith, W. H., & Wade, N. J. (1939) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)73454-6 · Cited by 123
GROWTH-promoting effect of aureomycin on pigs.
Jukes, T. H., Stokstad, E. L. R., Tayloe, R. R., Cunha, T. J. F., Edwards, H. M., & Meadows, G. B. (1950) · PubMed · Cited by 110
THE SEQUENCE OF PATHOLOGIC EVENTS IN THE DEVELOPMENT OF EXPERIMENTAL FATTY LIVER AND CIRRHOSIS
Hartroft, W. S. (1954) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1954.tb36440.x · Cited by 62
Fatty Liver Following Aureomycin and Terramycin Therapy in Chronic Hepatic Disease
Sborov, V. M., & Sutherland, D. A. (1951) · Gastroenterology · doi:10.1016/s0016-5085(51)80131-8 · Cited by 56
GERMFREE ANIMALS AND LIVER NECROSIS
Luckey, T. D., Reyniers, J. A., György, P., & Forbes, M. (1954) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1954.tb36472.x · Cited by 52
Polymyxin B and polymyxin E; clinical and laboratory studies.
Kagan, B. M., KREVSKY, D. A., MILZER, A., & Locke, M. (1951) · PubMed · Cited by 44
LABORATORY AND CLINICAL STUDIES OF POLYMYXIN B AND E 12
Pulaski, E. J., Baker, H. J., Rosenberg, M. L., & Connell, J. F. (1949) · Journal of Clinical Investigation · doi:10.1172/jci102134 · Cited by 42
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Roth, R. A., & Ganey, P. E. (2002) · CRC Press eBooks · doi:10.1201/9781420032208-32
Guaiume, E. A. (2005) · MOspace Institutional Repository (University of Missouri)
Biomarkers of Organ Injury from Chemical Exposure
Ganey, P. E., & Roth, R. A. (2002) · CRC Press eBooks · doi:10.1201/9781420032208.sec5
Ethanol-Induced Hepatotoxicity
Beier, J. I., & Arteel, G. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95666-6
Carter, P. M. (1973) · The Lancet · doi:10.1016/s0140-6736(73)93093-6
Ethanol-Induced Hepatotoxicity
Arteel, G. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00272-2
Microbiome and Diseases: Steatotic Liver Disease
Bergheim, I., & Schneider, K. M. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_17
THE ROLE OF ENDOTOXINS IN HALOTHANE-ASSOCIATED LIVER INJURY.
Lind, R. C. (1982) · UA Campus Repository (The University of Arizona)
Metadata
- Authors
- Rutenburg, A. M., Sonnenblick, E., Koven, I., Aprahamian, H. A., Reiner, L., & Fine, J.
- Affiliations
- Harvard University (US)
- ORCID
- Fine, Jacob
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1957-07-01
- Volume
- 106
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2136738
- OpenAlex
- W2108335279
- Cited by
- 108
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- choline-deficient diet, intestinal bacteria, non-absorbable antibiotics, hepatic steatosis, rats
- MeSH terms
- Animals, Bacteria, Intestines, Liver Cirrhosis, Liver Cirrhosis, Experimental, Rats
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