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DELAYED HYPERSENSITIVITY-TYPE GRANULOMA FORMATION AND DERMAL REACTION INDUCED AND ELICITED BY A SOLUBLE FACTOR ISOLATED FROM SCHISTOSOMA MANSONI EGGS
Open accessAbstract
A soluble material has been isolated from schistosome eggs which in minute quantities without the addition of adjuvant induces sensitization to a delayed hypersensitivity type of granuloma forming around intact schistosome eggs. This material is secreted by intact eggs and is found in high concentration in the fluid released during the hatching process. When adsorbed to bentonite particles this substance elicits hypersensitivity type granuloma formation in specifically sensitized animals. The granuloma sensitizing factor also both induces and elicits delayed footpad swelling in mice. Quantities which sensitize with respect to these delayed type reactions do not induce antibody formation detectable by a sensitive hemagglutination. technique within the duration of the above experiments.
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Cited by
Ross, A. G. P., Bartley, P. B., Sleigh, A. C., Olds, G. R., Li, Y., Williams, G. M., & McManus, D. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra012396 · Cited by 870
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.021 · Cited by 396
CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development
MacDonald, A. S., Straw, A. D., Bauman, B., & Pearce, E. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1982 · Cited by 280
Metadata
- Authors
- Boros, D. L., & Warren, K. S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1970-09-01
- Volume
- 132
- Issue
- 3
- Pages
- 488-507
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2065902165
- Cited by
- 488
- References
- 0
- FWCI
- 16.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: DELAYED HYPERSENSITIVITY-TYPE GRANULOMA FORMATION AND DERMAL REACTION INDUCED AND ELICITED BY A SOLUBLE FACTOR ISOLATED FROM SCHISTOSOMA MANSONI EGGS. https://app.cochat.ai/papers/10.1084/jem.132.3.488
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- Boros, D. L., & Warren, K. S. (1970). DELAYED HYPERSENSITIVITY-TYPE GRANULOMA FORMATION AND DERMAL REACTION INDUCED AND ELICITED BY A SOLUBLE FACTOR ISOLATED FROM SCHISTOSOMA MANSONI EGGS. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.132.3.488
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
