The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development
Abstract
Whether dendritic cells (DC) play a passive or active role in Th2 response induction is poorly understood. In this study, we show that CD8− DC pulsed with Th2-polarizing Ag (soluble egg Ag (SEA)) from Schistosoma mansoni potently stimulate Th2 responses in vivo and in vitro while failing to undergo a conventional maturation process. Thus, in contrast to DC pulsed with the Th1 response inducing Ag Propionebacterium acnes, SEA-exposed DC exhibit a phenotype that is most similar to that of immature DC, failing to up-regulate expression of CD40, CD54, CD80, CD86, or OX40L; producing no detectable IL-4, IL-10, or IL-12; and displaying only a minor increase in MHC class II expression. Importantly, in vitro derived DC exposed to SEA were phenotypically similar to CD8− DC isolated from active S. mansoni infection. By discriminating between different types of pathogen and responding appropriately, CD8− DC play a major role in the decision process to mount either a Th1 or Th2 response.
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Cites
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M-1/M-2 Macrophages and the Th1/Th2 Paradigm
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Cited by
Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation
Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood · doi:10.1182/blood-2009-10-249540 · Cited by 1,246
Self-citationHelminth infections and host immune regulation
McSorley, H. J., & Maizels, R. M. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05040-11 · Cited by 499
van Die, I. (2003) · Glycobiology · doi:10.1093/glycob/cwg052 · Cited by 316
Steinfelder, S., Andersen, J. F., Cannons, J. L., Feng, C. G., Joshi, M., Dwyer, D., Caspar, P., Schwartzberg, P. L., Sher, A., & Jankovic, D. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082462 · Cited by 294
Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response?
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Metadata
- Authors
- MacDonald, A. S., Straw, A. D., Bauman, B., & Pearce, E. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-08
- Volume
- 167
- Issue
- 4
- Pages
- 1982-1988
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1881253097
- Cited by
- 280
- References
- 48
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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