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FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES
Open accessAbstract
Antigen activation of DNA synthesis in immune thymus-derived lymphocytes of guinea pigs requires the cooperation of macrophages and lymphocytes. We have investigated the role of histocompatibility determinants in this macrophage-lymphocyte interaction using cells from inbred strain 2 and 13 guinea pigs. The data demonstrate that efficient presentation of macrophage-associated antigen to the lymphocyte requires identity between macrophage and lymphocyte at some portion of the major histocompatibility complex. The failure of allogeneic macrophages to effectively initiate immune lymphocyte proliferation was not the result of the presence of an inhibitor of blastogenesis released in mixtures of allogeneic cells, peculiarities of the antigen or lymphoid cells employed, nor differing kinetics of activation by allogeneic macrophages. In addition, data were presented that demonstrated that alloantisera inhibit lymphocyte DNA synthesis by functional interference with macrophage-lymphocyte interaction.
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Citations
Cited by
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
T-cell antigen receptor genes and T-cell recognition
Davis, M. M., & Bjorkman, P. J. (1988) · Nature · doi:10.1038/334395a0 · Cited by 3,202
A BIOLOGICAL ROLE FOR THE MAJOR HISTOCOMPATIBILITY ANTIGENS
Doherty, P. C., & Zinkernagel, R. M. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92610-0 · Cited by 492
Induction of Macrophage Tumoricidal Activity by Granulocyte-Macrophage Colony-Stimulating Factor
Grabstein, K. H., Urdal, D. L., Tushinski, R. J., Mochizuki, D. Y., Price, V. L., Cantrell, M. A., Gillis, S., & Conlon, P. J. (1986) · Science · doi:10.1126/science.3083507 · Cited by 412
Metadata
- Authors
- Rosenthal, A. S., & Shevach, E. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1973-11-01
- Volume
- 138
- Issue
- 5
- Pages
- 1194-1212
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2103320120
- Cited by
- 1,036
- References
- 0
- FWCI
- 19.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES. https://app.cochat.ai/papers/10.1084/jem.138.5.1194
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- Rosenthal, A. S., & Shevach, E. M. (1973). FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.138.5.1194
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
