The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Induction of Macrophage Tumoricidal Activity by Granulocyte-Macrophage Colony-Stimulating Factor
Abstract
Monocytes are a subpopulation of peripheral blood leukocytes, which when appropriately activated by the regulatory hormones of the immune system, are capable of becoming macrophages—potent effector cells for immune response to tumors and parasites. A complementary DNA for the T lymphocyte-derived lymphokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), has been cloned, and recombinant GM-CSF protein has been expressed in yeast and purified to homogeneity. This purified human recombinant GM-CSF stimulated peripheral blood monocytes in vitro to become cytotoxic for the malignant melanoma cell line A375. Another T cell-derived lymphokine, γ-interferon (IFN-γ), also stimulated peripheral blood monocytes to become tumoricidal against this malignant cell line. When IFN-γ activates monocytes to become tumoricidal, additional stimulation by exogenously added lipopolysaccharide is required. No such exogenous signals were required for the activation of monocytes by GM-CSF.
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Cites
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The Cell Biology of Macrophage Activation
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FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES
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Expression of human immune interferon cDNA in E. coli and monkey cells
Gray, P. W., Leung, D. W., Pennica, D., Yelverton, E., Najarian, R., Simonsen, C. C., Derynck, R., Sherwood, P. J., Wallace, D. M., Berger, S. L., et al. (1982) · Nature · doi:10.1038/295503a0 · Cited by 689
Recombinant interferon-gamma increases HLA-DR synthesis and expression.
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ALTERATIONS OF MACROPHAGE FUNCTIONS BY MEDIATORS FROM LYMPHOCYTES
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Cited by
The Human Hematopoietic Colony-Stimulating Factors
Clark, S. C., & Kamen, R. (1987) · Science · doi:10.1126/science.3296190 · Cited by 1,639
Wodnar-Filipowicz, A., Heusser, C. H., & Moroni, C. (1989) · Nature · doi:10.1038/339150a0 · Cited by 480
Metadata
- Authors
- Grabstein, K. H., Urdal, D. L., Tushinski, R. J., Mochizuki, D. Y., Price, V. L., Cantrell, M. A., Gillis, S., & Conlon, P. J.
- Venue
- Science
- Published
- 1986-04-25
- Volume
- 232
- Issue
- 4749
- Pages
- 506-508
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4244591305
- Cited by
- 412
- References
- 22
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grabstein, K. H., Urdal, D. L., Tushinski, R. J., Mochizuki, D. Y., Price, V. L., Cantrell, M. A., Gillis, S., & Conlon, P. J. (1986). Induction of Macrophage Tumoricidal Activity by Granulocyte-Macrophage Colony-Stimulating Factor. Science. https://doi.org/10.1126/science.3083507
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
