The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM
Open accessAbstract
Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37°C, 0.10 M relative salt concentration and pH 7.5–8.0; it required calcium ions. It was mediated by a heat-stable nondialyzable factor which separated with C-reactive protein (CRP) during fractionation and purification, correlated with serum CRP levels, and, like other known reactivities of CRP, was inhibited by phosphoryl choline. Preparations of CRP purified either from serum or ascites resulted in consumption of large amounts of C1, C4, and C2 when preincubated with normal serum and protamine. We conclude that CRP is a potent activator of the C system at the level of C1, and that polycations such as protamine sulfate are substrates of CRP which can bring about this activation. It seems not unlikely that one role of CRP in health and disease involves its ability to interact with the C system.
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Cites
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Mancini, G., Carbonara, A. O., & Heremans, J. F. (1965) · Immunochemistry · doi:10.1016/0019-2791(65)90004-2 · Cited by 9,139
Serological reactions in pneumonia with a non-protein somatic fraction of Pneumococcus
Tillett, W. S., & Francis, T. (1930) · Journal of Experimental Medicine · doi:10.1084/jem.52.4.561 · Cited by 1,482
Kaplan, M. H., & Volanakis, J. E. (1974) · PubMed · Cited by 563
Complement and complement fixation
Mayer, M. M. (2010) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · Cited by 445
Specificity of C-Reactive Protein for Choline Phosphate Residues of Pneumococcal C-Polysaccharide
Volanakis, J. E., & Kaplan, M. H. (1971) · Experimental Biology and Medicine · doi:10.3181/00379727-136-35323 · Cited by 396
A PLASMIN-SPLIT FRAGMENT OF C'3 AS A NEW CHEMOTACTIC FACTOR
Ward, P. A. (1967) · The Journal of Experimental Medicine · doi:10.1084/jem.126.2.189 · Cited by 257
C5 Chemotactic Fragments Produced by an Enzyme in Lysosomal Granules of Neutrophils
Ward, P. A., & Hill, J. H. (1970) · The Journal of Immunology · doi:10.4049/jimmunol.104.3.535 · Cited by 243
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Immune Adherence by the Fourth Component of Complement
Cooper, N. R. (1969) · Science · doi:10.1126/science.165.3891.396 · Cited by 147
Time sequence of acute phase reactive proteins following surgical trauma
Crockson, R. A., Payne, C., Ratcliff, A. P., et al. (1966) · Clinica Chimica Acta · doi:10.1016/0009-8981(66)90030-1 · Cited by 144
Cited by
The physiological structure of human C-reactive protein and its complex with phosphocholine
Thompson, D., Pepys, M. B., & Wood, S. P. (1999) · Structure · doi:10.1016/s0969-2126(99)80023-9 · Cited by 818
Griselli, M., Herbert, J., Hutchinson, W. L., Taylor, K. M., Sohail, M., Krausz, T., & Pepys, M. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1733 · Cited by 508
Pathogenesis and Pathophysiology of Pneumococcal Meningitis
Mook-Kanamori, B. B., Geldhoff, M., van der Poll, T., & van de Beek, D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-11 · Cited by 492
Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product narp.
O’Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., & Worley, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80782-5 · Cited by 471
The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II
Bharadwaj, D., Stein, M.-P., Volzer, M., Mold, C., & Clos, T. W. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.4.585 · Cited by 391
Metadata
- Authors
- Siegel, J., Rent, R., & Gewurz, H.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1974-09-01
- Volume
- 140
- Issue
- 3
- Pages
- 631-647
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2129178261
- Cited by
- 256
- References
- 13
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Siegel, J., Rent, R., & Gewurz, H. (1974). INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.140.3.631
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
