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Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid.
Open accessAbstract
Amyloid fibrils were studied from two different tissues of medullary carcinoma of the thyroid (MCT). The fibrils mainly consisted of a low molecular weight protein, AMCT, which was immunologically distinct and did not react with various antisera against known amyloid fibril proteins. A specific antiserum raised against the MCT amyloid proteins gave a reaction of identity with the degraded MCT amyloid fibrils from two patients, as well as with the isolated AMCT protein, but showed no reaction with other known amyloid proteins. The AMCT protein had a blocked N terminus, but the sequence analysis of a cyanogen bromide fragment revealed identity with human calcitonin in the 11 positions studied. Although the amino acid composition was similar, there were also distinct differences, and the mol wt of 5,700 daltons was considerably larger than that of calcitonin. For these reasons the AMCT protein may represent a prohormone of calcitonin.
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Cited by
Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044
Self-citationWestermark, P., Wernstedt, C., Wilander, E., Hayden, D. W., O'Brien, T. D., & Johnson, K. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3881 · Cited by 976
Self-citationWestermark, P., Wernstedt, C., Wilander, E., & Sletten, K. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90708-4 · Cited by 512
Self-citationFolding versus aggregation: Polypeptide conformations on competing pathways
Jahn, T. R., & Radford, S. E. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.05.015 · Cited by 428
Lukinius, A., Wilander, E., Westermark, G. T., Engstr�m, U., & Westermark, P. (1989) · Diabetologia · doi:10.1007/bf00285291 · Cited by 371
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Metadata
- Authors
- Sletten, K., Westermark, P., & Natvig, J. B.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1976-04-01
- Volume
- 143
- Issue
- 4
- Pages
- 993-998
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2112196611
- Cited by
- 265
- References
- 0
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sletten, K., Westermark, P., & Natvig, J. B. (1976). Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid. The Journal of experimental medicine. https://doi.org/10.1084/jem.143.4.993
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