The DOI matches its Crossref record.
Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.
Open accessAbstract
Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11-HETE and 5-HETE. The human neutrophil chemotactic activity of the HETE products exhibited a rank-order of potency with 5-HETE greater than 8-HETE = 9-HETE greater than 11-HETE = 12-HETE. The expression of chemokinetic activity as well as chemotactic activity suggested that the endogenous production of these principles may influence the mobility of human neutrophils.
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Citations
Cited by
Ford-Hutchinson, A. W., Bray, M. A., Doig, M. V., Shipley, M. E., & Smith, M. J. H. (1980) · Nature · doi:10.1038/286264a0 · Cited by 2,060
Initiation of lipid peroxidation in biological systems
Kanner, J., German, J. B., Kinsella, J. E., & Hultin, H. O. (1987) · C R C Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398709527457 · Cited by 382
Oxidation of Polyunsaturated Fatty Acids: Mechanisms, Products, and Inhibition with Emphasis on Fish
Hsieh, R. J., & Kinsella, J. E. (1989) · Advances in Food and Nutrition Research · doi:10.1016/s1043-4526(08)60129-1 · Cited by 366
Hydroxyeicosatetraenoic acids (HETEs)
Spector, A. A., Gordon, J. A., & Moore, S. A. (1988) · Progress in Lipid Research · doi:10.1016/0163-7827(88)90009-4 · Cited by 302
Release and metabolism of arachidonic acid in human neutrophils.
Walsh, C. E., Waite, B. M., Thomas, M. J., & DeChatelet, L. R. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68951-9 · Cited by 279
Metadata
- Authors
- Goetzl, E. J., & Sun, F. F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1979-08-01
- Volume
- 150
- Issue
- 2
- Pages
- 406-411
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2132211952
- Cited by
- 260
- References
- 0
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Goetzl, E. J., & Sun, F. F. (1979). Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. The Journal of experimental medicine. https://doi.org/10.1084/jem.150.2.406
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
